Play our strongest XI that most posters have already named. Hopefully we'll get ourselves into a position where we can remove the likes of KDB and coast through the latter stages of the match. Actually, if we can afford to sub Kompany off early or he doesn't have to exert himself too much, i'd play him again against Southampton rather than West Ham. Mangala, for all his faults, is well suited to coming up against against Carroll or Ayew whereas the likes of Shane Long are more likely to expose his weakness on the ball if we're going to use him next week. Either way, with Southampton in no real form, also playing on the Sunday and having to travel to the Etihad, that's the game to sit one or two key players out rather than Huddersfield.
I'm sure everybody wants to see more of Foden and Brahim immediately but since Zinchenko can't play against Shakhtar, why not use him against Southampton. Fitness aside he looked okay against Wolves and given the opportunity in an otherwise strong back four, we might find he can offer a more naturally attacking left back option than Danilo, at least in home games we expect to dominate against teams struggling in the bottom half.
But Huddersfield have had some decent results at home so let's not take any chances just yet.