Yes it went Vancouver(nearly 3000 miles) > Toronto(still 500 miles) > New York in a 7 day span... flying late at night, fitting in time to train and media commitments. Not what you want before a derby.
Compare that with NYRB? Washington(225 miles) > Home Game > NYCFC
To put these distances in some kind of perspective, they're roughly equivalent to City playing in a derby having faced away trips to Ekaterinburg (in the Urals, over 1000 miles east of Moscow) and Paris in the preceding week, while United have had a trip to London and a home game.