Coronavirus (2021) thread

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ell said:
Its weird the countries that have handled it badly, UK, SA, Brazil all seeing significant variants but the Swedes haven't even though they now admit they got things wrong. I'm sure at one point they were on the travel corridor list too.
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Numbers game. It's very interesting that the mutation that has occurred in South Africa that enables it to escape an antibody reaction has occurred independently in the UK. We are seeing the same mutation in different strains across the world. What this tells you is that there are certain structures which are stable and confer an advantage and will repeatedly occur across the world wherever there is a lot of virus. We could stop all travel to South Africa, and we'd still end up with strains carrying similar mutations to the SA variant. We are seeing that happen. If we are really smart we will work out what the next mutations are going to be before they even happen. We know what the human receptor cell looks like on the molecular level. We know that the spike protein looks like. The changes that are effective are those that produce a stronger binding affinity between the two molecules. Swap amino acid residues, add extra ones, delete others. You can probably do it with a computer program.

Molecular simulations are done all the time where you take a sequence of amino acids and put in in a solvent and then watch it fold. It's called Molecular Dynamics simulations. You apply forcefields such as the Lennard Jones Potential and then run Monte Carlo simulations which move the molecule picometers and sum up all the different interactions step by step so that you can model how the molecule will form. You can make your model in a computer and then check it with X-ray diffraction.
 
paulchapo said:
I'm becoming more worried about the government than the virus. This is never going to end I'm afraid, that is becoming clearer by the day.
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Just like AIDS, the scientists and medical community will eventually, through hard work, knowledge, a degree of serendipity and experience treat and contain the virus to make it something we can live with without affecting everyday life. I wouldn't be too pessimistic and I'm hopeful this will be the last really challenging year in the fight against Covid.
 
mosssideblue said:
Of course you don't because your problem is, you don't see all the additional costs associated in running a Covid Hotel.
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So they walk in stay in their room for 10 days and it’s cleaned when they leave are you telling me it costs over £1000 per person to do this? Maybe i should apply for a job as a cleaner then.
 
KnaresboroughBlue said:
I assume his point is that if it is cheap enough, it will encourage more people to do it. By making the price so high, it should hopefully discourage people. I might be wrong though.
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I would think the 10 days would be more of put off mate, cantbsee why anyone wants to holiday here at the moment and if it’s business people then zoom would be better
 
hammocity said:
Just like AIDS, the scientists and medical community will eventually, through hard work, knowledge, a degree of serendipity and experience treat and contain the virus to make it something we can live with without affecting everyday life. I wouldn't be too pessimistic and I'm hopeful this will be the last really challenging year in the fight against Covid.
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It isn't the medical side I'm overly worried about we appear to be making great strides there. I'm more worried the government appear to have sweeping powers to impose draconian laws, punitive punishments and restrictions using the virus as a reason. Has a state of emergency been declared, or martial law? If so I've missed it.
 
Grant Shapps is full of shit. On radio four this morning saying do not book foreign or domestic holidays. I distinctly remember him last year on radio 4 saying there would be no foreign holidays last year and waxing lyrical about holidays in this country and how great they are. Fast forward two months and there he is in Spain having to return early to avoid having to self isolate for 14 days
 
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Citizen of Legoland said:
There's a political thread in the sub-forum separately where it will be tolerated.
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And by tolerated you mean basically not read as hardly anyone uses that thread. Its just a place for mods to dump any posts from here that mention the Tories as if they are somehow separate from it all, when they're clearly not. If we're talking restrictions we're talking politics.
 
hammocity said:
Just like AIDS, the scientists and medical community will eventually, through hard work, knowledge, a degree of serendipity and experience treat and contain the virus to make it something we can live with without affecting everyday life. I wouldn't be too pessimistic and I'm hopeful this will be the last really challenging year in the fight against Covid.
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I’m confident too that we will be on top of the virus this year. What we don’t know is how much lasting damage has been done to to health services across the globe including the NHS. There’s an assumption that as soon as the hospital cases get a bit lower we will start getting back towards normality. The realistic is that this pandemic might do lasting damage to workforces.

Today on Radio 5 Live, a Chief Nurse broke down who has leadership for 4 ICUs and 170 staff in Wales. There is still a big strain on their services that isn’t getting better at the moment. I recall how many people came back from the Gulf wars with PTSD and it’s possible that we may see something similar across health and social care. Fingers crossed we recover well but other posters wanting pubs, gyms and shops to open next week need to understand how damaging the pandemic has been.
 
paulchapo said:
It isn't the medical side I'm overly worried about we appear to be making great strides there. I'm more worried the government appear to have sweeping powers to impose draconian laws, punitive punishments and restrictions using the virus as a reason. Has a state of emergency been declared, or martial law? If so I've missed it.
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The government has been very liberal, it's a situation without precedent for all of us living through this. The feckless amongst our society have made this an almost impossible task at times and hopefully lessons will have been learnt. My main point was don't be too pessimistic, our law of democracy will always prevail in the end, there's no military Junta in place to impose martial law or declare a state of emergency.
 
hammocity said:
The government has been very liberal, it's a situation without precedent for all of us living through this. The feckless amongst our society have made this an almost impossible task at times and hopefully lessons will have been learnt. My main point was don't be too pessimistic, our law of democracy will always prevail in the end, there's no military Junta in place to impose martial law or declare a state of emergency.
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I'm trying, I really am trying to keep positive but I have reached real low points just recently. This announcement overnight that anyone lying about where they've travelled from can be imprisoned for TEN years astonished me. How can this be possible without parliamentary discussion and a vote? Yet all over the country pandemic or not kids are stabbing and killing one another and I don't see such a huge response to stop that.

It's the constant lies and shifting of the goalposts too. Just six weeks, just three months, just until we have a vaccine, just until the vulnerable are vaccinated, now it's when EVERYONE is vaccinated and as if that's not enough it's now when the whole world is vaccinated. It's like psychological torture.
 
Be interesting to see how many of those first dose recipients had actually contracted cv previously based on recent findings on the effectiveness of the jab on people who had previously got cv, look forward to the UK version of this graph appearing in a British tabloid near you some time soon without the journo's scary caveats inserted

 
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