Coronavirus (2021) thread

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This is why the SA variant is important...

Skelly et al. Preprint.

Vaccine-induced immunity provides more robust heterotypic immunity than natural infection to emerging SARS-CoV-2 variants of concern.

Our data confirm that VOC, particularly those with substitutions at residues 484 and 417 escape neutralization by antibodies directed to the ACE2-binding Class 1 and the adjacent Class 2 epitopes but are susceptible to neutralization by the generally less potent antibodies directed to Class 3 and 4 epitopes on the flanks RBD.

In other words the SA variant escapes 2 important antibody reactions induced by vaccination.

It does however generate a strong T cell response.
 
Regional England hospital data

P (Patients) V (Ventilated) up /down v last Thursday


East P down 175 to 2262 (v 3052) // V down 24 to 221 (v 290)

London P down 200 to 4079 (v 5212) // V down 17 to 888 (v 1032)

Midlands P Down 237 to 4021 (v 4986) // V down 27 to 530 (v 629)

NE & Yorks P Down 30 to 2817 (v 3255) // V up 6 to 308 (v 322)

North West P Down 84 to 2916 (v 3557) // V down 16 to 326 (v 364)

South East P Down 121 to 2710 (v 3632) // V down 10 to 354 (v 443)

South West P Down 96 to 1178 (v 1276) // V down 4 to 153 (v 195)


As with all the other parts of the UK hospital numbers all going the right way but as with its cases the North West - whilst falling - not quite doing so on pace with the others.
 
Sometime today the 4 millionth person in the UK will have tested positive for Covid.

The number from yesterdays data sits at 3, 998, 655 right now.
 
Marvin said:
This is why the SA variant is important...

Skelly et al. Preprint.

Vaccine-induced immunity provides more robust heterotypic immunity than natural infection to emerging SARS-CoV-2 variants of concern.

Our data confirm that VOC, particularly those with substitutions at residues 484 and 417 escape neutralization by antibodies directed to the ACE2-binding Class 1 and the adjacent Class 2 epitopes but are susceptible to neutralization by the generally less potent antibodies directed to Class 3 and 4 epitopes on the flanks RBD.

In other words the SA variant escapes 2 important antibody reactions induced by vaccination.

It does however generate a strong T cell response.
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So the vaccine works on the SA variant?
 
zerox said:
I think it safe to assume, that the mention of a bus, is an example, and not to be taken literally
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Invisible Man's Bandage said:
Just had a text to book my first shot. I'm 66 with no pre existing conditions and I'm in at Clarendon Leisure Centre on Monday morning.

I'm extremely pleased with this.
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I got a similar text this morning I’m 67 and like you no vulnerability, am going tomorrow afternoon in York
 
Berts Neck said:
Thanks for all you efforts, much appreciated..can I ask, is that Covid deaths or total deaths ?? As I understand it, any person who gets Covid and dies within 4 weeks from whatever cause, is included in the stats. So if Covid only deaths, the figures may reflect things from 4 weeks ago and are in fact likely to be much better today. Does that make sense ?
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worsleyweb said:
I could not post the other day as I wanted to check with my mate it would not be getting him into trouble but my friend at AZ has stated to me in the strongest possible terms that the vaccine works against all strains sufficiently enough to do the job and has implied the scare stories are just just keep us compliant a while longer.
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That data was only on the Pfizer jab though. Are you saying they have as yet unpublished data on the AZ jab that supports this too?

Though I think it very likely if one does then they all will to some extent at least.

It also seems wise to rein people in a bit. My friend after she had the Pfizer jab was expecting to be immune the next day and I had to caution her to wait another 3 weeks as recommended.

It will be easy to see it as liberation day once you have the first vaccination. It has been a long year.

The one thing the AZ vaccine did for me is give me my best nights sleep on Tuesday after having it that I have had for weeks. Are you sure they do not put some brandy in there?
 
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Gabriel said:
Promising.
https://www.theguardian.com/world/2021/feb/11/pfizer-vaccine-strong-response-new-covid-variants
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That's the same paper I posted before and it confirms that a couple of the neutralising antibody reactions no longer occur in the case of the SA variant.

It maybe sufficient to hold the virus off, or reduce the severity of illness but I think fears about ongoing transmission are going to lead to an extended lockdown until we see whether other mutations form. If experience shows that transmission is at such low levels or that the mutations leads nowhere dangerous then we can lift restrictions further.
 
worsleyweb said:
I could not post the other day as I wanted to check with my mate it would not be getting him into trouble but my friend at AZ has stated to me in the strongest possible terms that the vaccine works against all strains sufficiently enough to do the job and has implied the scare stories are just just keep us compliant a while longer.
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It wont stop transmission which means the lockdown will go on until we see the effect on mutation. Unless we use another more effective vaccine....if there is one. There maybe
 
worsleyweb said:
if I had to guess I would say 20 million have had it.
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Very probably a lot more, of course. But that 4 million is 'proven' minimum base level. The rest beyond is largely guesswork

And now we know reinfection is possible especially via new variants probably not that important as herd immunity is a much harder target if we allow new variants to spread as easily as our modern world inevitably does.

If our modern science was as now but we were still travelling the world on steam ships then this pandemic would be over by now. Almost every victory by the virus has occurred because air travel is seen as indispensable and it gives a free ride to Covid.
 
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Marvin said:
It wont stop transmission which means the lockdown will go on until we see the effect on mutation. Unless we use another more effective vaccine....if there is one. There maybe
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If hospitalisations and deaths are at July 2020 figures, I cannot see them locking down, transmissions or not.

Large crowds will be banned and it’ll be social distancing but retail and hospitality will open.
 
Marvin said:
It wont stop transmission which means the lockdown will go on until we see the effect on mutation. Unless we use another more effective vaccine....if there is one. There maybe
Click to expand...

They already have a vaccine for the variants in the works.
Ready for Aug/Sept. Approval will be faster because they are similar to the current vaccines.
From what i read, they may be rolled out as a kind of booster shot. (even if you have already had the main one etc)
 
fulabeer said:
Am i reading this right?
Looks like a 25% (ish) drop across the three main figure last week.

UKHSA data dashboard

Showing public health data across England
coronavirus.data.gov.uk coronavirus.data.gov.uk
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The wave peaked around 19 Jan and everything everywhere has been falling since yes. Though it started earlier with lockdown and vaccines in turn starting to impact. But much of the fall in hospital patients and deaths have been in the last 2 to 3 weeks. Those follow cases falling with death numbers the last thing to change.
 
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