It's gonna happen and it won't be just one game. I'm a NFL fan and love heading to London to watch one of the 3 games every year when it comes over. This year it's expanded even more and there are games in Ireland, Spain and Germany as well. As most clubs only get 8 or 9 home games a season, that's a big loss if your team heads abroad.
It happens in Rugby League now to a certain extent with the Super Weekend (and I think a team went to Vegas this year)
If 14 US Owners own PL teams this year, then soon after a whole selection of games will head to the States. Wouldn't surprise me to see a whole weekend of fixtures spread across the whole of the USA and using the East coast and west coast timezones to ensure only 1 PL match at a time is being played.
I would hate it if we lost a home game, especially if it was against the dippers, rags or tarquins, but that also makes me a bit of a hypocrite as I love the London NFL games.
It's coming, will fans band together to stop it ?