COVID-19 — Coronavirus

[mancity1]

Worldwide the serious / critical condition rate is reducing and is the death rate of closed cases.

Positive signs.

Countries that have good contract tracing and quarantine programs have already got on top of the pandemic but many have had to do so at the expense of overseas travellers and the boost to the economy that brings.

Notwithstanding the advances in treatment and disease control since 1918 this pandemic is not as lethal and the Spanish flu by some margin.

We will get on top of this in 2021 vaccine or no vaccine in my opinion provided this doesn't mutate on a large scale.

 

[03 March 2002]

The results this week on Pfizer for example are great but the Pfizer vaccine will require a very complex cold chain (storage and transport at -70c until it's administered) and a system for doing this for over 100 million+ doses doesn't exist yet.

Blown hugely out of proportion unfortunately. In analytical science we've been mass transporting samples all over Europe and indeed the world on dry ice for years and years. Anywhere worth mentioning will have several -70c storage freezers. Don't worry about this aspect at all.

 

[Healdplace]

Northern Ireland 3 wks ago v 2 wks v last wk v today

Deaths: 5 v 9 v 10 v 8 today

Cases : 1039 v 840 v 679 v 791 today - first real increase week to week in a while. Hopefully a blip.

7 day rolling cases total 6693 v 6255 v 4498 v 3886 today

Patients : 289 v 352 v 418 v 441 today

Ventilated 32 v 37 v 42 v 35

The hospital numbers have slowed and the ventilators plateaued - which is good. But deaths here are part of the reason.

 

[mosssideblue]

Blown hugely out of proportion unfortunately. In analytical science we've been mass transporting samples all over Europe and indeed the world on dry ice for years and years. Anywhere worth mentioning will have several -70c storage freezers. Don't worry about this aspect at all.

Are these storage conditions not required at every GP surgery and any other facility being earmarked for administering the vaccine

 

[ayrshire_blue]

Ages of infections in scotland

133 people aged 65+
31 of whom are 85+

108 kids under 15
23 of whom are aged under 5

179 aged 15-24

841 aged 25-64


***Deaths***

25 people aged 85+
18 people aged 75-84
12 people aged 65-74
9 people aged 45-64

 

[mancity1]

Blown hugely out of proportion unfortunately. In analytical science we've been mass transporting samples all over Europe and indeed the world on dry ice for years and years. Anywhere worth mentioning will have several -70c storage freezers. Don't worry about this aspect at all.

Co2 to the rescue again.

 

[kaz7]

Worldwide the serious / critical condition rate is reducing and is the death rate of closed cases.

Positive signs.

Countries that have good contract tracing and quarantine programs have already got on top of the pandemic but many have had to do so at the expense of overseas travellers and the boost to the economy that brings.

Notwithstanding the advances in treatment and disease control since 1918 this pandemic is not as lethal and the Spanish flu by some margin.

We will get on top of this in 2021 vaccine or no vaccine in my opinion provided this doesn't mutate on a large scale.

The states have more people in hospital now than at the peak of the first wave so i dont agree with your assumptions

 

[03 March 2002]

Are these storage conditions not required at every GP surgery and any other facility being earmarked for administering the vaccine

It's not a difficult logistical question. Storage at -70c if not available on-site (as I've said in a previous post, I fully expect this to change to -20c and hopefully 2-8c soon after authorisation) -> transport on dry ice (-70-80c) -> thaw and administer

 

[kaz7]

Blown hugely out of proportion unfortunately. In analytical science we've been mass transporting samples all over Europe and indeed the world on dry ice for years and years. Anywhere worth mentioning will have several -70c storage freezers. Don't worry about this aspect at all.

Bollocks i am afraid , the out of hospitals setting dont have that facility ,gp surgeries and care homes certainly dont and they have to be able to store them because giving the jab is time consuming as they have to be drawn up and double checked before use, it is a huge logistical problem

 

[blue b4 the moon]

Blown hugely out of proportion unfortunately. In analytical science we've been mass transporting samples all over Europe and indeed the world on dry ice for years and years. Anywhere worth mentioning will have several -70c storage freezers. Don't worry about this aspect at all.

Had my flu jab today, the nurse said they didn't have storage facilities at the temp needed

 

[mosssideblue]

Had my flu jab today, the nurse said they didn't have storage facilities at the temp needed

This is what I asked, but it seems our resident itk, is satisfied we don't need to

 

[Healdplace]

England hospital deaths in detail

Today's highest ever wave 2 number 361 has some big numbers, of course. But this hopefully should be the highest numbers until next week. If it isn't then that may well be a concern.

10 Nov adds 40 = 40 after 1 day (34 was added last week)

9 Nov adds 164 = 203 after 2 days. (122 was added last week). This is the biggest daily add on in 6 months, And the highest day 2 total (and first over 200) since 6 May. Same as Scotland's death data today went back.

8 Nov adds 71 - 213 after 3 days, (52 was added last week). This is also the biggest and first over 200 3 day total since 6 May.

7 Nov adds 42 = 235 after 4 days. (38 was added last week). This is the highest daily total deaths ascribed to any day in wave 2 and the highest since May 7 even after 6 months of add ons to every day since. And the highest day 4 total since 1 May.

6 Nov adds 24 = 209 after 5 days, (18 was added last week) 4 of the last 6 five day totals have been over 200. After none before that since 7 May.

5 Nov adds 4 and = 202 at 6 days and 4 Nov adds 5 and - 228 at 7 days.

The other add ons were onto nine further different dates back to 15 Oct. These are getting too numerous to add and I am sure nobody really needs to know that October 30 now has had 193 deaths instead of 192.

So unless there is something necessary to record I will stick to the first week of numbers from now onward.

When it gets possible to do otherwise it will mean numbers have tumbled and we have turned the corner.

 

[Summerbuzz]

Reasonable article on the subject;

Reuters | Breaking International News & Views

Find latest news from every corner of the globe at Reuters.com, your online source for breaking international news coverage.

uk.reuters.com

Apparently, assuming the vaccine is transported in an ultracold state, and delivered in a standard refrigerator, there is 5 day window in which to administer the doses before they spoil - which can be extended through restocking dry ice and only opening the freezer once a day. How practical this is, I dunno.

 

[03 March 2002]

Bollocks i am afraid , the out of hospitals setting dont have that facility ,gp surgeries and care homes certainly dont and they have to be able to store them because giving the jab is time consuming as they have to be drawn up and double checked before use, it is a huge logistical problem

As far as I understand it this candidate is to be transported at -70c, easily done, and can be stored in the fridge for a max of 5 days thereafter. They won't need to be stored at the place of administration and a roll out plan will mean that the vaccines are divvied out as per requirements.

I'll say again, by the time this hits the market I'll be surprised to see this isn't stored at -20c or better, 2-8c. At the end of the day it's encapsulated in a lipid nanoparticle. I've worked with such therapeutics and actually found they are annoyingly stable. To the point where you have to use 'aggressive' techniques to break down the lipids to get at the damn thing.

 

[Healdplace]

This is what I asked, but it seems our resident itk, is satisfied we don't need to

I posted last night what Matt Hancock said on the storage issues. Regions are being asked to set up by 1 Dec GP surgeries that DO in every region covering up to 3 surgeries - so most patients will likely have to go further afield than their own local surgery.

In the first run though it will be care home patients and staff and over 80s so most of them likely cannot even get to surgeries.

 

[mancity1]

The states have more people in hospital now than at the peak of the first wave so i dont agree with your assumptions

Worldwide Kaz , and we are taking about serious/critical cases as a percentage of total cases.

Don't forget in the states especially in New York they were dying at home in big numbers and that genius of a bureaucrat in New York let covid positive people back into nursing homes.

Even idiotic governments like the one we have in Victoria who are not only inept but corrupt as well as I have well documented and the State Premier should have resigned long ago have got the number down to zero in Melbourne albeit after locking us in our own homes for 4 months.

 

[lancs blue]

Reasonable article on the subject;

Reuters | Breaking International News & Views

Find latest news from every corner of the globe at Reuters.com, your online source for breaking international news coverage.

uk.reuters.com

Apparently, assuming the vaccine is transported in an ultracold state, and delivered in a standard refrigerator, there is 5 day window in which to administer the doses before they spoil - which can be extended through restocking dry ice and only opening the freezer once a day. How practical this is, I dunno.

Thanks for the link, I was about to ask how quickly the vaccine degrades at "normal" fridge temperatures.

 

[Healdplace]

So today's three nation case total (without England) is 2980.

Versus 3740 (3 wks ago) v 3456 (2 wks ago) v 3314 (last wk)

So a steady if unspectacular fall over the month.

Last week's 3314 became 25, 177 when the England cases were added.

 

[mosssideblue]

I posted last night what Matt Hancock said on the storage issues. Regions are being asked to set up by 1 Dec GP surgeries that DO in every region covering up to 3 surgeries - so most patients will likely have to go further afield than their own local surgery.

In the first run though it will be care home patients and staff and over 80s so most of them likely cannot even get to surgeries.

Lost me a little. Are you saying places that will administer the vaccine will have to have dry ice storage conditions?

 

[kaz7]

As far as I understand it this candidate is to be transported at -70c, easily done, and can be stored in the fridge for a max of 5 days thereafter. They won't need to be stored at the place of administration and a roll out plan will mean that the vaccines are divvied out as per requirements.

I'll say again, by the time this hits the market I'll be surprised to see this isn't stored at -20c or better, 2-8c. At the end of the day it's encapsulated in a lipid nanoparticle. I've worked with such therapeutics and actually found they are annoyingly stable. To the point where you have to use 'aggressive' techniques to break down the lipids to get at the damn thing.

How is it going to go from 70c to. 2-8 c ? This is meant to be rolled out in the next few weeks . Not point saying there are not going to be problems in distribution, storage and administration because they are obvious , people will have to be patient