I don't think he can . Considering the kick off time of this match and the Burnley match in the weekend there won't be enough time for players to recover for the weekend game. And the PL game is a must win unlike this one .Pep will play his strongest eleven as he will want to win this game to get qualification asap as he has done every year.
The last two CL games he'll have the opportunity to rest players especially around the derby game at the swamp.