Coronavirus (2021) thread

Status
Not open for further replies.
twosips said:
Yeah I saw that earlier. Nearly shared it on here but thought i'd get abuse. Curious to see what that's based on though. Bit odd! Midly concerning though as apparently its come from Handelsblatt, not Bild. They'are seemingly more reliable, so would be good to have this cleared up I guess.
Click to expand...
never stopp posting mate of the fear of abuse,you have the ignore button so fuck them off
 
Any article like that is going to gain traction so irrespective of whether its correct or not, regulators and scientists alike will have to respond to it.

And preferably soon.
 
Invisible Man's Bandage said:
They have been saying that since the roll out began but they are adding capacity weekly. Another 32 large sites open this week so you would think that if supply was constrained then they wouldn't expand capacity.

My feeling is that for once they want to over deliver rather than promise the earth and not. I also think they don't want other European countries to know how much supply we actually have so that they can't pressure manufacturers to divert supplies to them.
Click to expand...
You could be right, hopefully you are, I prefer for now to be cautiously optimistic, not wildly.
 
Del_Bosque said:


Filing this one under bitter agenda driven bollocks
Click to expand...


I will speculate.

The UK information for healthcare professionals quotes:

The number of COVID-19 cases (2) in 660 participants ≥65 years old were too few to draw conclusions on efficacy

and

However, in this subpopulation, immunogenicity data are available, see below.

www.gov.uk

Summary of Product Characteristics for Vaxzevria - Last updated November 2023

www.gov.uk www.gov.uk

In other words, the trial proved efficacy in the overall population, but the approval depends on showing equivalent immune response (antibody generation) in older subjects rather than efficacy directly.

My guess is that the very small numbers in the older age group means there is a very large confidence interval on efficacy in that age group, and the lower limit of the confidence interval is 8%. If so, it absolutely does not mean efficacy is 8%, and the MHRA view is that the demonstration of equivalent immune response is sufficient to justify temporary authorisation.

As I said, just speculation.
 
kaz7 said:
The vaccination programme is going really well but then the nhs are experts at it , all the gov need to do is keep giving it to them
Click to expand...
We've never been here before. This is way above what the NHS can handle alone. Many agencies joining forces on this including the military. I know people who are giving up their weekends to get this over the line.
www.instituteforgovernment.org.uk

Coronavirus vaccine rollout | Institute for Government

The vaccine rollout is the responsibility of the Department of Health and Social Care (DHSC).
www.instituteforgovernment.org.uk www.instituteforgovernment.org.uk
 
Gaylord du Bois said:
We've never been here before. This is way above what the NHS can handle alone. Many agencies joining forces on this including the military. I know people who are giving up their weekends to get this over the line.
www.instituteforgovernment.org.uk

Coronavirus vaccine rollout | Institute for Government

The vaccine rollout is the responsibility of the Department of Health and Social Care (DHSC).
www.instituteforgovernment.org.uk www.instituteforgovernment.org.uk
Click to expand...
Never on this scale granted but the basics are well honed by the nhs
 
somapop said:
Yes, I will do v soon. They’ve actually helped with the cough. Obviously painful in the lungs/throat constantly coughing so it’s eliminated much of that.

Also I said hell would (ironically) freeze before I sat with a hot water bottle...I’m now seriously considering marrying mine. As warm & as full of unconditional love as a the greatest lovers.
Click to expand...
Girlfriend had a minor op on Saturday and yesterday asked me to do the hot water bottle for her, fucking air in it as I put the water in so it bubbled out all up my arm and wrist!! Fucking sore as fuck.
 
roubaixtuesday said:
I will speculate.

The UK information for healthcare professionals quotes:

The number of COVID-19 cases (2) in 660 participants ≥65 years old were too few to draw conclusions on efficacy

and

However, in this subpopulation, immunogenicity data are available, see below.

www.gov.uk

Summary of Product Characteristics for Vaxzevria - Last updated November 2023

www.gov.uk www.gov.uk

In other words, the trial proved efficacy in the overall population, but the approval depends on showing equivalent immune response (antibody generation) in older subjects rather than efficacy directly.

My guess is that the very small numbers in the older age group means there is a very large confidence interval on efficacy in that age group, and the lower limit of the confidence interval is 8%. If so, it absolutely does not mean efficacy is 8%, and the MHRA view is that the demonstration of equivalent immune response is sufficient to justify temporary authorisation.

As I said, just speculation.
Click to expand...
I’d also add according to Scottish figures so far 45% of over 80s have been done and 96% of total vaccinations so far were with the pfizer which surprised me this afternoon. Don’t know for England.
Is it possible Pfizer is being used on the older and most vulnerable first, maybe most over 70s?
 
Few words on the longevity of antibodies; this is the study current best knowledge is based on in the UK. That those with antibodies or a previous positive PCR have much lower reinfection rate than not.

The study concludes that after 5 months of follow up on this cohort, "prior SARS-CoV-2 infection protects most individuals against reinfection for at least five months".

Further follow up will provide more data but it is extremely likely, given the prevalence of antibodies after 5 months, that they'll last longer than that. Best knowledge = min 5 months for the vast majority

www.medrxiv.org

Do antibody positive healthcare workers have lower SARS-CoV-2 infection rates than antibody negative healthcare workers? Large multi-centre prospective cohort study (the SIREN study), England: June to November 2020

Background There is an urgent need to better understand whether individuals who have recovered from COVID-19 are protected from future SARS-CoV-2 infection. Methods A large multi-centre prospective cohort was recruited from publicly funded hospital staff in the UK. Participants attended regular...
www.medrxiv.org www.medrxiv.org
 
worsleyweb said:
go on kaz! Give Hancock some praise for buying the vaccines early! You can do it!
Click to expand...
They did buy them early that is true , along with astra zeneka taking a financial hit on getting it made despite it not being licensed , that side of things has been well done , credit where it is due , about the only thing they have got right mind you
 
Claytop said:
Girlfriend had a minor op on Saturday and yesterday asked me to do the hot water bottle for her, fucking air in it as I put the water in so it bubbled out all up my arm and wrist!! Fucking sore as fuck.
Click to expand...

Karma that for the park run mate comment the other day!!!
 
kaz7 said:
They did buy them early that is true , along with astra zeneka taking a financial hit on getting it made despite it not being licensed , that side of things has been well done , credit where it is due , about the only thing they have got right mind you
Click to expand...

financial support? Not done bad at all on that either.
 
Status
Not open for further replies.
Unread Posts

Don't have an account? Register now and see fewer ads!

SIGN UP
Back
Top