Coronavirus (2021) thread

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blueparrot said:
I’d expect redesign to have started already, though it may need more than one. Either way I think both doses will be complete by the end August, some of those in phase 2 may get already adjusted ones.
If redesigned boosters are needed for those being vaccinated now, I’d guess they will be single shots from November ish. Good thing is we should be capable of running through 30mill shots in a couple of months.
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There's something in the news suggesting Astrazeneca talking about October as a date for a variant vaccine
 
Healdplace said:
Boris calls for a 6 pm national clap for Captain Tom tonight.
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My wife has a slightly different view of him to most. She reckoned he was a ‘nasty bastard’ (her words & not mine) after reading extracts of his book where he was very insulting to his first wife and very dismissive of her obvious mental health issues. She was also disgusted that he was saying these things as his former wife was dead and clearly had no-one to defend her.

I doubt my wife will be clapping tonight...
 
Marvin said:
There's something in the news suggesting Astrazeneca talking about October as a date for a variant vaccine
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That is likely when we will need to revaccinate the at risk population for the winter alongside the flu jab so makes sense to aim for that

Indeed they might even be able to combine into one jab eventually though this year it might be two like when you have a pneumonia booster same year as flu every now and then.
 
KS55 said:
There is also the suggestion that ASTRA ZENECA jab reduces transmission.
Meanwhile, Macron and others continue to say this drug is not safe or not effective and UK taking risks. No evidence at all for these assertions. Disgraceful. Presumably, then, the French will not want any of this jab.
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This really isn't true, as far as I know.
France and Germany have not said it's not safe. Neither have they said it's not effective.
They've said that in the over 65 age group, the trials have not provided enough data to be certain.

I'm sure AZ will be looking to fix that, but it is a perfectly acceptable ethical position to not allow injection of something which has no guaranteed effect.

Today's transmission report may well change that opinion as it may indicate a benefit, just as trials in the older agegroups would provide data.

The UK position is that there isn't data for the older groups, but that it has a benefit for younger agegroups and does not seem to have negative effects - therefore they've given an emergency use order for it.
 
Wales vaccination update:

462, 497 First doses - 22, 857 given yesterday - was 23, 334 day before

1160 Second doses - 94 given yesterday - was 496 day before
 
Scotland data:

88 deaths - was 92 last week

978 cases - was 1330 last week

5.1% positivity - was 6.3% last week

1871 patients - down 63 on yesterday - was 1971 last week

128 on ventilators - down 12 on yesterday - was 145 last week
 
MillionMilesAway said:
The UK position is that there isn't data for the older groups, but that it has a benefit for younger agegroups and does not seem to have negative effects - therefore they've given an emergency use order for it.
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The position is actually much stronger than that, and has also been approved by the European Medicines Agency (and others worldwide).

It it this:

1) The AZ vaccine is effective across all age ranges, taken as a whole, as demonstrated in the phase 3 trial
2) There is insufficient evidence form the phase three trial to quantify the benefit in the over 65s standalone
3) The phase 2 study shows equivalent immune response (antibodies) in all age ranges including the over 65s
4) The phase 2 results justify bridging efficacy from the general population to the over 65s cohort.

I've posted the antibody response against age before, but here it is again anyway

1612355975400.png


 
Healdplace said:
Scotland data:

88 deaths - was 92 last week

978 cases - was 1330 last week

5.1% positivity - was 6.3% last week

1871 patients - down 63 on yesterday - was 1971 last week

128 on ventilators - down 12 on yesterday - was 145 last week
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Deaths only slightly lower doesnt fill me with confidence that we will see ant significant drop elsewhere, still expecting over 1200 deaths in total to be announced again today. I really hoped these numbers would have been well below 1000 a day on a regular basis and dropping quickly by now :(
 
Gaylord du Bois said:
They are, apparently, only contacting one person per household.
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so they contacted two here...........within an hour of each other...........one days after a positive test result. The Tees Valley Public health have been way way better - contacted both by phone within 2 hours of respective positive tests - took details of movements and recent contacts and are in touch daily by text or call.......thats what cheap, cheerful and publicly run gets you
 
Nicola Sturgeon just stated exactly what I got attacked in here for saying yesterday.

That it is wrong that England are only saying how many people have been 'offered' vaccine as opposed to how many have 'had' a vaccination - especially in the over 80s.

Gove was apparently asked this directly and refused to clarify.

Glad someone sees as I do why the use of this word is not meaningless semantics.

It is vital clarification of crucial information.

They have to know the number and not revealing it just creates the impression (even if it is not true) that they do not want us to see the answer.

Either way Nicola tells us that 87% of all those who are 80 and over in the community and 98% of those in care have actually HAD at least one vaccination - not just been 'offered' one.
 
roubaixtuesday said:
The position is actually much stronger than that, and has also been approved by the European Medicines Agency (and others worldwide).

It it this:

1) The AZ vaccine is effective across all age ranges, taken as a whole, as demonstrated in the phase 3 trial
2) There is insufficient evidence form the phase three trial to quantify the benefit in the over 65s standalone
3) The phase 2 study shows equivalent immune response (antibodies) in all age ranges including the over 65s
4) The phase 2 results justify bridging efficacy from the general population to the over 65s cohort.

I've posted the antibody response against age before, but here it is again anyway

View attachment 9507


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Thanks, I've not considered the phase 2 trials data; I don't know how much weight they carry in regulation processes.

I do think that point 4 is where the difference is, and there is different weight given to it by different national regulators. It looks like Germany/France nationally have prioritised point 2; the UK have considered point 2 in combination with points 3 and 4. I don't think either are right or wrong, as I don't think there is a right/wrong on this.
 
abu13 said:
Deaths only slightly lower doesnt fill me with confidence that we will see ant significant drop elsewhere, still expecting over 1200 deaths in total to be announced again today. I really hoped these numbers would have been well below 1000 a day on a regular basis and dropping quickly by now :(
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If you look at the number by date of death, it is below 1000 now, latest date for data is 31st Jan, and it fell below 1000 on 26th Jan (last Tuesday).

The headline number each day is misleading, we have 5 high numbers during the week, and 2 low numbers at weekends.
 
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