By calling it a manufactured disease I take you subscribe to the lab leak theory. Personally I think it’s a possibility but it will be some time before it’s proven one way or the other.
I agree that no one knows the long term effects of a brand new disease that we know can leave lasting effects on the heart, lungs, and other internal organs but we have a pretty good idea what the long term effects of the vaccine are due to the fact that around three quarters of the world’s population have had it including many countries with robust reporting systems for negative effects. There are clearly negative effects on a very small percentage of the population as there are with any vaccine but every serious study has demonstrated that the risk of serious harm from the vaccine is a fraction of the risk of serious harm from the disease. That’s why most people who understand risk will take the vaccine rather than leave themselves exposed to the higher risk of complications with the disease.