* Stuart Adamson - Musician, and founder of The Skids and Big Country. Born in Manchester.
* Caroline Aherne - BAFTA award winning actress, comedian and writer; The Mrs Merton Show
* Mark Addy - Albert Medal recipient.
* Don Arden - Cheetham Hill-born music manager and businessman, best known for overseeing the careers of rock groups Small Faces, Electric Light Orchestra and Black Sabbath.
* Michael Atherton - former England cricket team captain and commentator.
* Gary Barlow - Lead singer from the Manchester band Take That
* Stu Bennett - Professional wrestler known by his ring name Wade Barrett
* Anthony Burgess - author, poet, playwright, musician, linguist, translator and critic, most famous for his novel A Clockwork Orange.
* Wes Brown- Manchester United Footballer
* Ian Brown musician, best known as the former lead singer of the alternative rock band The Stone Roses.
* John Cassidy, an Irish-born sculptor and painter who lived in Manchester.
* Peter Cundall OA, a horticulturist and television presenter born in Manchester.
* Ian Curtis musician and singer in Joy Division.
* Northside singer/lyricist Dermo, born, raised and living in Manchester.
* Mark Davies, Bishop of Shrewsbury.
* Ashley Taylor Dawson, British actor born and raised in Manchester
* Liam Gallagher - lead singer of Manchester band Oasis.
* Noel Gallagher - songwriter and lead guitarist for Manchester band Oasis.
* Brian Kidd - An English football coach, (currently assistant manager at Manchester City) and former player. He was assistant manager to Alex Ferguson at Manchester United in the 1990s was a member of the Manchester United team that won the European Cup in 1968.
* Harold Lever - Labour politician and Baron of Manchester.
* David Lloyd George - British Prime Minister during the First World War and member of the Liberal party.
* Bernard Manning - Ancoats-born stand-up comedian.
* Ian McShane - An English actor who grew up in Manchester
* Steven Patrick Morrissey singer in The Smiths.
* Karl Pilkington - Comedian on the Ricky Gervais Show podcasts and new television series An Idiot Abroad
* Emmeline Pankhurst - Suffragette[21]
* Thomas de Quincey - An English author and intellectual, best known for his Confessions of an English Opium-Eater (1821).[22]
* Philip Sampson (1980-), cricketer who has represented Buckinghamshire, the Surrey Cricket Board and Surrey.
* Peter Saville - Manchester-born artist and designer, best known for his work with Factory Records.
* Nobby Stiles MBE - Collyhurst - An English former football midfielder. He was the toothless midfield ballwinner of England's 1966 World Cup winning squad. Stiles, Bobby Charlton and Ian Callaghan are the only Englishmen to have won both World and European Cups.
* Shaun Ryder - vocalist and songwriter with the Happy Mondays who became famous in the Madchester era.
* John Thaw - actor best known for his roles in The Sweeney, Inspector Morse and Kavanagh QC.
* J. J. Thomson - A physicist and Nobel laureate, credited for the discovery of the electron and of isotopes, and the invention of the mass spectrometer. He was awarded the 1906 Nobel Prize in Physics for the discovery of the electron and his work on the conduction of electricity in gases.