Technically, sure. But we've played this way many times before.
We can and have played systems where one of the fullbacks is more advanced than the other and the other plays more like a 3rd CB.
It os not hard to envision a Scenario where a 3 of (Gvardiol, Guehi, Dias and Khusanov) play plus an attacking RB in Trent. Allowing us to overload the middle as the RW ( most likely Cherki/ Semenyo) plays more inside and let's Trent have the wide area.
For what its worth, Trent really isnt a major overlapping full back. A majority of his crosses are from the areas Kev used to like belting crosses from.
While unlikely to happen, I can comfortably see Pep loving a player with Trent's skillset.