The high line has been even more exposed with Demichellis in the back four, partially with Kolarov as well. They're not the fastest and as Vardy and Deulofeu showed a high line with those two is suicidal. However, with Vinnie and Otamendi I'd feel more confident as they both have decent enough pace. Think Vinnie showed that in the first minutes on Wednesday when he kept up with Yarmolenko before slide tackling him. I'd still rather play a deeper line, with a less static edge of the offside routine mind. For this reason Clichy has to play.
In regards to the Yaya conundrum I think it's quite simple. Exactly how we lined up with him at Seville. In a two with Fernandinho with Fernando anchoring behind. Or even what we set up with at Kiev, although it'd be imperative that Silva dropped a lot with would lose some of his attacking impetus.