COVID-19 — Coronavirus

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Claytop said:
2 or 3 months apart sounds a very long time?

Surely not right?
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well the AZ ceo interviewed by Sunday times said they had come up with a dosing regimen so the efficiecy was up near 90% (with Moderna and Pfizer)

Had heard they were looking at spacing out rather than the half/full dosing mentioned

more data must have been submitted since the initial findings

if it can prevent severe disease and death after one dose then 90% immunity after 2 that would be amazing
 
worsleyweb said:
Absolutely fucking raging! The ex wife who is a teacher and her partner who is also a teacher had 14 for Xmas day from 4 households. They also had a separate family around on Boxing Day. My wife and I did not see our parents on Xmas day. The kids obviously come between both houses. The ex has now lost her sense of smell and taste and her partner is ill and her mum who has major health issues a cough. All awaiting test results. The selfish cow - I am so angry I feel like calling the school. She has placed me at risk and my dad (I do his shopping) and my wife’s parents through her total selfishness. I am so bloody angry.
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That beggars belief but sadly quite common.
I hope she's ok purely for your kids sake but hopefully she'll act more responsibly going forward.
Take care mate.
 
Ric said:
I think it’s inevitable now. Feels like it’s spiralling out of control so decisive action is needed.
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Unfortunately true decisive action would have been seeing what was coming weeks ago and decisively acting before it got this bad. It was not hard to predict where we would be. Half this forum was discussing it and pointing out what needed to be done.

Now its a long way down from where we will be given Christmas was handled very badly with a message many ignored. That will come home to roost in January before the vaccines really get a chance to turn the corner. And could have been avoided with a unified 4 nation approach, far more sense about the need to have Christmas and way better messaging which has been terribly handled throughout.

If we go for aything else but a national lockdown it will be yet another in a long list of errors because I know hardly anyone who understands the current tiers so just does what they want and hope it is right. Create more tiers with more rules that will just accelerate non compliance.

Simple all the same lockdown rules work because there is no get around or better off place to escape towards so you end up doing more of the right things because the option to do the wrong ones is much reduced.

I hope they see this and we do not get yet another patchwork quilt with Tier 5 added.

But not terribly optimistic they will see why swift application of simplicity matters.
 
Del_Bosque said:
well the AZ ceo interviewed by Sunday times said they had come up with a dosing regimen so the efficiecy was up near 90% (with Moderna and Pfizer)

Had heard they were looking at spacing out rather than the half/full dosing mentioned

more data must have been submitted since the initial findings

if it can prevent severe disease and death after one dose then 90% immunity after 2 that would be amazing
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Thank you. That makes sense of an interview with one of the scientists I saw on TV in the middle of the night on some channel or other when I was half awake. I have referred to it a few times since as it implied they traded off early permission to go ahead because they had done new trials over recent weeks that boosted the evidence and turned out even better than they had hoped. Hence it was worth waiting a few weeks to get approval withy a method that worked at a level that compared far better with the one already in use. As there were concerns that the 62% v 90% 'success' rates would deter some from having the vaccine early and saying they would wait for more of the 'better' one.

They also noted that they were most excited at the level with which it stopped anyone even if they caught Covid from not getting sick enough to go to hospital and their results on that marker were far better than the more successful at stopping you catching Covid at all' ones.

If I heard all this right (I was half awake) it makes a lot of sense as nobody is really judging vaccines on how good they are at stopping you needing to go to hospital - just on how good they are at stopping you catching it at all.

And yet getting it and it being just like a cold and not needing to take hospital beds might be more important in the next couple of months than anything else given the pressure the NHS is under and will be under from many things as they always are in Jan/Feb.

Let us hope all these stories mesh together and we do get that vaccine next week. As with it we will be well on the way to beating this thing. Without it the new year will be much longer and harsher.

Oxford will be the game changer. It getting approved and doing what they seem to believe will be a huge boon to not just the UK but the rest of the world helping us to get back to real normality faster. As that will not happen if only we and the rich nations beat this virus. Everyone out there has to. And Oxford is their cheapest easiest best hope too,
 
worsleyweb said:
Absolutely fucking raging! The ex wife who is a teacher and her partner who is also a teacher had 14 for Xmas day from 4 households. They also had a separate family around on Boxing Day. My wife and I did not see our parents on Xmas day. The kids obviously come between both houses. The ex has now lost her sense of smell and taste and her partner is ill and her mum who has major health issues a cough. All awaiting test results. The selfish cow - I am so angry I feel like calling the school. She has placed me at risk and my dad (I do his shopping) and my wife’s parents through her total selfishness. I am so bloody angry.
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Sorry to hear that worselyweb. Really annoying to say the least.
 
Claytop said:
2 or 3 months apart sounds a very long time?

Surely not right?
Click to expand...
There were suggestions that the Oxford vaccine's effectiveness was compromised by an immune response to the adenovirus. Perhaps a delay in the 2nd jab would lead to a reduced immune response. Complete guess and probably miles off.

I hoped that tomorrow's papers might have some news about the Oxford vaccine but I didn't find anything
 
www.livemint.com

Efficacy of Oxford jabs at 95% if given 3 months apart: SII

SII is manufacturing 50-60 million doses of Covishield a month and will increase its capacity to 100 million doses by March after commissioning its third plant.
www.livemint.com www.livemint.com

AstraZeneca Plc will soon release data showing that the effectiveness of its covid-19 vaccine rises to as much as 95% if the two shots are separated by about 2-3 months, said Adar Poonawalla, chief executive of Serum Institute of India (SII), the British company’s manufacturing partner.
"You’ll be hearing some good news from the UK very soon... It would be a 90-95% effective vaccine if you just keep a two-to-three months’ gap between dose 1 and dose 2. They will make that public with documentation," Poonawalla said at a press conference on Monday.
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your anger only effects you, not who your anger is directed at. Take a step back, for your own good.
 
worsleyweb said:
Absolutely fucking raging! The ex wife who is a teacher and her partner who is also a teacher had 14 for Xmas day from 4 households. They also had a separate family around on Boxing Day. My wife and I did not see our parents on Xmas day. The kids obviously come between both houses. The ex has now lost her sense of smell and taste and her partner is ill and her mum who has major health issues a cough. All awaiting test results. The selfish cow - I am so angry I feel like calling the school. She has placed me at risk and my dad (I do his shopping) and my wife’s parents through her total selfishness. I am so bloody angry.
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Wipe the fucking floor with her pal. What an absolute thundercunt.
 
“
Having studied evidence on both the Pfizer/BioNTech and Oxford University/AstraZeneca vaccines, the JCVI has advised the priority should be to give as many people in at-risk groups their first dose, rather than providing the required two doses in as short a time as possible.

Everyone will still receive their second dose and this will be within 12 weeks of their first. The second dose completes the course and is important for longer term protection.

From today the NHS across the UK will prioritise giving the first dose of the vaccine to those in the most high-risk groups. With two vaccines now approved, we will be able to vaccinate a greater number of people who are at highest risk, protecting them from the disease and reducing mortality and hospitalisation.

The JCVI’s independent advice is that this approach will maximise the benefits of both vaccines. It will ensure that more at-risk people are able to get meaningful protection from a vaccine in the coming weeks and months, reducing deaths and starting to ease pressure on our NHS.”

from Gov website
 
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