Coronavirus (2021) thread

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I've read it and the NY times article and sadly 2021 is going to be a wash.

By the time we vaccinate for the original virus then the UK/SA variant and then whatever new variant(s) comes out it'll be over a year.

Would be interesting to hear whether the original variant with no vaccine is more, or less dangerous than the new variant with the 'version 1 vaccine' that doesn't protect as much as first thought?
I said only last week on here that this was my concern. We will end up playing wack a mole with the different variants for absolutely years.

I also think we need to be careful. Keep putting different cocktails into your arm will lead to complications itself.
 
I saw this video which conveniently started when the Police officer attacked the Cafe Worker. I did wonder what happened beforehand and now we no.

Fuckwits.
I saw the same one and the number of people defending the cafe owner is alarming.

I really do feel sympathetic towards the police. They’re sent to break up these events where they’re unarmed and their powers limited. And if they do try to actually enforce anything, they have a camera thrown into their face in the effort to distort actual events.

Fed up of people citing “civil liberties” for acting like idiots and it’s becoming increasing clear why we’re in the mess that we’re in. Too many people in the UK act like they’re living in a totalitarian state. Thankfully, the real ones in the world are usually censored to such an extent they wouldn’t get the chance to laugh at us.
 
I'd love Boris to come out and say "Listen up! Enough's enough - next cafe or party host goes to jail for a month."
It's that kind of action that might finally get through to people.
 
I saw the same one and the number of people defending the cafe owner is alarming.

I really do feel sympathetic towards the police. They’re sent to break up these events where they’re unarmed and their powers limited. And if they do try to actually enforce anything, they have a camera thrown into their face in the effort to distort actual events.

Fed up of people citing “civil liberties” for acting like idiots and it’s becoming increasing clear why we’re in the mess that we’re in. Too many people in the UK act like they’re living in a totalitarian state. Thankfully, the real ones in the world are usually censored to such an extent they wouldn’t get the chance to laugh at us.

The selfish pondlife knobheads in the cafe are the reason many businesses are still closed and infections are through to the roof.

Police have a tough task on their hands taking on a new crime with the same resources on top of other crimes going on.
 
The selfish pondlife knobheads in the cafe are the reason many businesses are still closed and infections are through to the roof.

Police have a tough task on their hands taking on a new crime with the same resources on top of other crimes going on.

Although some police officers are born wankers and do take the piss with exercising their power.

Like anywhere though, there's always a minority of dickheads.
 
Not caught up lately with this virologist guy on Twitter but I remember from the start of the pandemic his clarity & voice of reason (he always insisted a vaccine was the only way out).


Can anyone explain the bit about AZ vaccine variants being problematic in terms of immune response due to viral vectors? Kind of reads that the technology is limited compared to some of the others?
 
The Harry rags!

Good luck to @Cassandra today, hope all goes well.
Thanks Ayrshire, I ventured outside South Ayrshire for the first time since October to go even as far as Drongan Community Centre - a first for me. The administration was slick and efficient, my vaccine was given by a young lady who was being trained and under instruction, I would have felt more confident if she had been wearing a mask that covered her nose properly. However, faced with someone approaching me with a needle in hand cowardice got the better of valour and I said nothing. So I will have added one to yesterday's total of the vaccinated - if the rest of Scotland was as busy as Drongan it should be quite a high number. I returned to the car to hear the news about the AZ vaccine (which I'd just had) being less effective against the South African strain .... I was also made to feel rather more elderly by the way I was asked questions - the tone was rather like that you would use to someone who was going doolally. When it got to the question "Do you know why you are here?" I was tempted to answer that that was a question that had puzzled mankind since time immemorial. But again I thought better of it.

So far I don't feel any after effects, I felt very tense and then excited watching the game in the afternoon and a little bit achy afterwards but that's quite usual.

I hope that you have now recovered from your encounter with the virus and are not suffering from any long term issues.

Best wishes
 
Thanks Ayrshire, I ventured outside South Ayrshire for the first time since October to go even as far as Drongan Community Centre - a first for me. The administration was slick and efficient, my vaccine was given by a young lady who was being trained and under instruction, I would have felt more confident if she had been wearing a mask that covered her nose properly. However, faced with someone approaching me with a needle in hand cowardice got the better of valour and I said nothing. So I will have added one to yesterday's total of the vaccinated - if the rest of Scotland was as busy as Drongan it should be quite a high number. I returned to the car to hear the news about the AZ vaccine (which I'd just had) being less effective against the South African strain .... I was also made to feel rather more elderly by the way I was asked questions - the tone was rather like that you would use to someone who was going doolally. When it got to the question "Do you know why you are here?" I was tempted to answer that that was a question that had puzzled mankind since time immemorial. But again I thought better of it.

So far I don't feel any after effects, I felt very tense and then excited watching the game in the afternoon and a little bit achy afterwards but that's quite usual.

I hope that you have now recovered from your encounter with the virus and are not suffering from any long term issues.

Best wishes

Pleased to hear you've had it done and with no or minimal side effects, that's great and must be a pleasant relief. It is strange though that the staff there aren't keeping safety measures to the highest standard with proper mask wearing etc. Can only hope that perhaps your experience is an isolated one in that respect and it doesn't reflect the approach in the majority amongst those delivering the vaccine. I think she would have appreciated your reply on existance btw =) pleased for you.
 
Can anyone explain the bit about AZ vaccine variants being problematic in terms of immune response due to viral vectors? Kind of reads that the technology is limited compared to some of the others?
There are no AZ vaccine variants. There were some question marks about the design of the AZ vaccine that have nothing to do with variants. The Sputnik vaccine uses a similar method to the Oxford vaccine but they use different viral vectors in Injection one and Injection two to avoid an immune response to the viral vector.
 
The vaccine has become a medicine that for the moment should prevent serious illness. That is still valuable though. If you don't get seriously ill, why worry about it?

That was my thoughts too, which is why I didn't really understand this particular follow up post from Kolchinsky, who as Somapop points out is very balanced and has never came across as sensationalist on any of his opinions, but I was a bit taken aback by this...



Interested to read how you interpret this, as perhaps the wording of his tweet maybe makes it seem worse than it it actually is?
 
Can anyone explain the bit about AZ vaccine variants being problematic in terms of immune response due to viral vectors? Kind of reads that the technology is limited compared to some of the others?

I think:
The AZ vaccine uses a chimpanzee adenovirus vector (a vector is essentially a bigger carrier compound that the specific agent is implanted into it - it makes sure the vaccine component specific for covid gets to the right part of cell machinery).
The point raised is that the body might start to recognise the adenovirus vector itself as a foreign body and create an immune response to deal with it - that could then prevent the vaccine reaching the machinery.

Other vaccines use different vectors.
 
Got invited to book a jab in Poynton by text last Friday.
Despite trying several times a day since I still can’t get an appointment.
GP just says if the link doesn’t work don’t bother us.
 
That was my thoughts too, which is why I didn't really understand this particular follow up post from Kolchinsky, who as Somapop points out is very balanced and has never came across as sensationalist on any of his opinions, but I was a bit taken aback by this...



Interested to read how you interpret this, as perhaps the wording of his tweet maybe makes it seem worse than it it actually is?


I think this runs on from the same point as above - that the body may start noticing the carrier adenovirus and nullify it. That would mean that the mRNA approach using that vector is redundant. I think that the "tolerably accommodate" here may relate to the amount of mRNA that can be dosed before the body combats the vector carrier.

Protein vaccines are likely to be the specific spike protein parts (or other protein produced by the virus) and not the RNA encoding them, and any immune response is going to be specific for them.
 
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