You don't want to be fighting it. If the action is too high for example then you will just get frustrated. Equally if it is so low that it is buzzing then you will also be on a hiding to nothing. A good setup can turn a horror to play into a pleasure and it is worth finding a good local guitar tech who can cast an eye over your guitar and make some improvements to its playability. It shouldn't cost a fortune but can make a massive difference.
Most guitars come from the factory with an action that is higher than it should be. It allows them to be set up to suit their new owners. You might prefer light strings and they ship with heavy or vice versa and changing these will usually need a truss rod tweak to adjust the relief (note I said relief, if anyone says they will alter your action by adjusting the truss rod run a mile!). Nut slots are typically a little shallower than ideal which will make it harder to play chords in the 1st position, exactly where you will be spending all your time as a beginner. Saddle height is something else they can look at but that makes more difference higher up the neck. Sometimes the neck simply is at the wrong angle and it needs to be completely reset. Again a good tech can advise you.
This should give you a good idea of what is involved. It is for an electric but the concepts hold true for acoustics too.
The other thing is it should be comfortable for you. You might be better with a shorter scale or a longer scale depending on your body size and shape- guitar bodies vary dramatically too- I much prefer a smaller 000/OM size to a Dreadnaught, it is much more comfortable for me. I also love guitars where the body meets the neck at the 12th fret rather than the usual 14th. It changes both the sound and the ergonomics of the whole thing.
You don't say if you have an electric or acoustic but different makes and styles have different neck profiles so don't be afraid to try as many as possible. There is no such thing as wrong or right, but there is right for you.
All these things can make the difference between you fighting it, so it is not playing nicely, or just being your friend that you always look forward to picking up. It's worth getting these basics right to get you on the right track at the beginning. As I said what make, what it looks like and even what it sounds like are really unimportant at the beginning.