Just sticking my head above the parapet to say I think Dzeko should start instead of Negredo, and no, my first name isn't Edin.
Reason two fold. I think Dzeko is the sharper of the two strikers at the moment. I think Negredo is the sort of bloke who would try and run off a lost leg, and wouldn't be surprised if the little he's played since his injury he really shouldn't have done. Secondly, I think Jovetic has a naturally better understanding with Dzeko than Negredo, and Jovetic surely has to play. Ergo, two strikers, one Jovetic, the other should be Dzeko. He also due a game where he smashes in a couple of brilliant goals.
Irrelevant as Negredo will probably start through virtue of not playing against Chelsea.
I'm more curious to see if Fernandinho starts. Against Barcelona in a midfield two with Yaya isn't quite what you'd call easing back into it!