Coronavirus (2021) thread

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I think all RNA treatments are linked to thrombocytopenia too?

So arguably equally likely to be a problem for RNA vaccines?
I don't think the mRNA vaccines are affected.

This is the Abstact of the paper I found. I searched for thrombocytopenia and adenovirus.

My emboldening. I haven't bothered reading it because there's stuff in the abstract such as Willebrand Factor, and P-selectin that I have never heard of but it sounds quite similar to the problems encountered with the COvid-19 vaccines.

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY| DECEMBER 5, 2006,
Volume 109, Issue 7
April 1 2007
Othman et al.

"Thrombocytopenia has been consistently reported following the administration of adenoviral gene transfer vectors. The mechanism underlying this phenomenon is currently unknown. In this study, we have assessed the influence of von Willebrand Factor (VWF) and P-selectin on the clearance of platelets following adenovirus administration. In mice, thrombocytopenia occurs between 5 and 24 hours after adenovirus delivery. The virus activates platelets and induces platelet-leukocyte aggregate formation. There is an associated increase in platelet and leukocyte-derived microparticles. Adenovirus-induced endothelial cell activation was shown by VCAM-1 expression on virus-treated, cultured endothelial cells and by the release of ultra-large molecular weight multimers of VWF within 1 to 2 hours of virus administration with an accompanying elevation of endothelial microparticles. In contrast, VWF knockout (KO) mice did not show significant thrombocytopenia after adenovirus administration. We have also shown that adenovirus interferes with adhesion of platelets to a fibronectin-coated surface and flow cytometry revealed the presence of the Coxsackie adenovirus receptor on the platelet surface. We conclude that VWF and P-selectin are critically involved in a complex platelet-leukocyte-endothelial interplay, resulting in platelet activation and accelerated platelet clearance following adenovirus administration."
 
England hospital deaths wk to wk

279 / 59 NW / 26% (25% fall wk to wk)

164 / 35 NW / 21% (41% fall wk to wk)

101 / 26 NW / 26% (378% fall wk to wk)

98 / 19 NW / 19% (3% fall wk to wk)

40 / 8 NW / 20% (61% fall wk to wk)

12 / 1 NW / 9% (70% fall wk to wk)

33 / 8 NW / 24% (175% RISE wk to wk) TODAY

Looks worse than it is I suspect! Hopefully!
Guessing last Tuesday’s low figure was down to the Easter break and not as many being reported as a result so not really a great barometer.
 
I don't think the mRNA vaccines are affected.

This is the Abstact of the paper I found. I searched for thrombocytopenia and adenovirus.

My emboldening. I haven't bothered reading it because there's stuff in the abstract such as Willebrand Factor, and P-selectin that I have never heard of but it sounds quite similar to the problems encountered with the COvid-19 vaccines.

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY| DECEMBER 5, 2006,
Volume 109, Issue 7
April 1 2007
Othman et al.

"Thrombocytopenia has been consistently reported following the administration of adenoviral gene transfer vectors. The mechanism underlying this phenomenon is currently unknown. In this study, we have assessed the influence of von Willebrand Factor (VWF) and P-selectin on the clearance of platelets following adenovirus administration. In mice, thrombocytopenia occurs between 5 and 24 hours after adenovirus delivery. The virus activates platelets and induces platelet-leukocyte aggregate formation. There is an associated increase in platelet and leukocyte-derived microparticles. Adenovirus-induced endothelial cell activation was shown by VCAM-1 expression on virus-treated, cultured endothelial cells and by the release of ultra-large molecular weight multimers of VWF within 1 to 2 hours of virus administration with an accompanying elevation of endothelial microparticles. In contrast, VWF knockout (KO) mice did not show significant thrombocytopenia after adenovirus administration. We have also shown that adenovirus interferes with adhesion of platelets to a fibronectin-coated surface and flow cytometry revealed the presence of the Coxsackie adenovirus receptor on the platelet surface. We conclude that VWF and P-selectin are critically involved in a complex platelet-leukocyte-endothelial interplay, resulting in platelet activation and accelerated platelet clearance following adenovirus administration."
Interesting. Why exactly is the administration of an adenovirus triggering a clotting cascade...
 
England hospital data is a little concerning for a Tuesday that usually shows good falls.

Patients are down - though only by 51 versus 92 last week and 183 the Tuesday before that.

Moreover the NW went UP quite a bit today - patients by 22 and ventilators by 4.

Just one day and let us hope it stays that way.

But ventilators in the SW also rose to double over past 3 days. Admittedly from just 6 to 12.

On the other hand Midlands and Yorkshire both fell by 31 and 33 respectively and London only went up 1.

So may just be a localised blip.
 
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