Coronavirus (2021) thread

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The fear with omicron is that the mutations in the spike protein will lead to vaccine evasion (and increased transmission).

What if the Chinese CoronaVac vaccine remains effective? It is a whole virus inactivated vaccine and should be less effected by changes in the spike protein.

Its rgearded as a very effective vaccine. For example, in Chile 75% of their vaccinations have been completed with CoronaVac. I am wondering how this performs against Omicron.

In the media they talk about vaccine evasion due to spike mutation but they forget that there are whole virus vaccines too. The South Africans must have thought about this option. So must the manufacturers of Coronavac. The UK and Europe have their own whole virus inactivated vaccines (Valneva) but I don't think it was as effective in trials.

You would think there would be some discussion about this, and some questions asked. But no.

Isn't it proven that Omicron has some evasion of natural previous infection immunity which would suggest inactivated vaccine will have issues?
 
Isn't it proven that Omicron has some evasion of natural previous infection immunity which would suggest inactivated vaccine will have issues?
Not necessarily, we still need to view this in the context of what is considered evasion, is that not getting COVID at all or is it just having mild symptoms?

If you catch this variant and only have mild symptoms then did the vaccine work? Arguably the answer to that is yes however certainly from a vaccine efficacy reporting point of view the vaccine has failed.

The only thing we're really interested in is serious disease and hospitalisations. Anecdotal evidence so far shows that Omicron does not cause serious disease in vaccinated people.

As with all previous strains of COVID though it has the real potential to become an even greater threat to the unvaccinated, and that potentially may include the previously infected too but it's far too early.
 
New data shows GSK-vir antibody treatment works against all omicron mutations..
 
Isn't it proven that Omicron has some evasion of natural previous infection immunity which would suggest inactivated vaccine will have issues?
An inactivated vaccine should create antibodies over a whole genome rather than a small subset. There's an argument to suggest that the spike gene would not be well conserved (contrary to what was first suggested).
 
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