Ideally you'd like to rest everyone but it's not going to happen and there's a few players who need minutes.
The likes of Stones, Kovacic, Nunes and Grealish could use the game time.
Fringe players like Ortega, Lewis, Gomez, Phillips and Bobb will surely start to give others a rest.
Akanji will probably start after sitting out against Luton and I'd expect Gvardiol to as well after being subbed.
I'd go with something like this:
-----------------------Ortega
Lewis-----Stones-----Akanji-----Gvardiol
-----------------------Philips
---------Kovacic---------------Nunes
Bobb--------------Grealish-------------Gomez
There's a chance we could lose with that team but we've already sewn up first place so it doesn't matter.
It would be great if we could leave the rest (Ederson, Walker, Dias, Ake, Rodri, Bernardo, Foden, Alvarez) at home and give them a full week off to prepare for Palace but I suspect most of them will still be in the squad.
The only thing that matters is no injuries.