I think it will
If you think about the last international break, Gundogan played three FULL matches for Germany. If it's likely that any player is anticipated to be in the same situation, then Pep won't play them this weekend, as the player would be playing four full games in two weeks and will come back knackered
If the player isn't going on international duty, then they're getting two weeks rest after the Everton game, so if the player is considered to be one of our best eleven (example Cancelo) then even if they played in the CL, there is no issue in selecting the player vs Everton with a break afterwards