Looking at these dates in conjunction with the PL fixtures is essential.
It's often when tricky PL fixtures coincide with CL games that league points are dropped. I would rather have some harder games earlier on when we can concentrate on them, without the coming CL match potentially distracting.
We have CL group game midweek before Liverpool away in November. As with last season Liverpool fixtures may decide the PL?
In December we have United Home, CL group game, then Arsenal Away.
In April we have Liverpool home Saturday, 1st leg CL 1/4 final midweek, Southampton away weekend, 2nd CL leg midweek, then Newcastle home weekend. Newcastle will presumably have new investment then so could be a different beast altogether next season.