At Barca Pep would regularly play Iniesta on the wing with Abidal as his fullback. I don't see why Laporte or Clichy could not play full back with Silva at left wing or Stones or Sagna at RB and Silva on the RW. My opinion is that Silva will play in the midfield 3 and on the wing and KDB will play on the wing, and as #10 and maybe even as a striker (very similar to what we have seen with Muller). These are really talented players and their skill sets are versatile. While positional discipline is key to his philosophy Pep is going to use that versatility and plan each game specifically if his history is any indication.
I think the make up of the midfield is going to be really interesting. Specifically, who else is going to play the pivote if Gundogan is first choice there? Can Nasri play that role? I think having at least 2 players in that role is a necessity.
Also will Nasri and Fernandinho get many games as a #8 or will we see Thiago or Pogba and the promotion of both Garcias from the academy. I expect Yaya and Fernando will not be around but there are a lot of things that will be fun to see play out.