According to Expedia:
No direct flights to Madrid from Manchester on the day of the game (Ryanair not on Expedia, see below).
To fly direct without going for more than 2 nights, the best you can do is 18:20 Iberia on the Monday, then 16:10 back with Iberia on the Wednesday…for the princely sum of £552!
For Ryanair, there’s only 1 direct flight on the day of the game but doesn’t get to Madrid til after kick off, sooo
Flying out Monday direct, coming back Wednesday direct…£734!
To do the same trip on the Thursday/Friday is £80 return. Scandalous