I think the difficulty in assessing the midfield pairing is that regardless of who we play in the two positions it's heavily reliant on really strong pressing from the front 4 ahead of them. With just 4 players instead of 5 in attacking positions it's going to be more difficult to create chances and pin teams back hence the importance of the press. We did it really well in the first half against Wolves.
You take away that press, and the front 4 become sitting ducks. Then whenever attacks break down and given that we're going to press whatever's going on it ends up with us being rather easy to slice through. Tiredness can cause this just as it did in the second half against Wolves.
This system we saw against Wolves might come unstuck if Aguero or Mahrez play, especially both. They can't press like any of the other attackers quite can, although they'll both give it a go and press when they can. When these two play, we'd probably need another player higher with De Bruyne to support the press and ensure that the likes of Aguero and Mahrez have the ball as much as possible to do their magic. I think a difficulty we had last season was that Gundogan nor Silva especially had the relentlessness to do that in the other #8 role, so the press failed again. And we were cut open again, and it's even worse with only one defensively positioned midfielder.
Although on top of this, this is where having top CBs helps us. Because when we get played through they can reliably deal with whatever comes against them. At least with a reasonable amount of success, as playing high up is going to get the better of even the best defenders from time to time. It means that whenever the press does go a bit awry the CBs can just mop shit up for long enough to give the pressing players a chance to get back up to it.
The only time a double pivot would work with us without the need of a super strong press is the rare occasion we play a team that presses us and we need a way to play out patiently, such as some recent fixtures against Liverpool and away at Real Madrid. But that's a really specific scenario.
Basically, the most important thing is that the front players (ie De Bruyne + front 3) press really well and the CBs don't shit the bed. The rest will take care of itself. Rodri, Fernandinho, and Gundogan, and Bernardo if he plays there all have enough quality and in game intelligence to ensure that as long as the first two conditions are met then they can support both attack in control and press and defence in whatever way is necessary.