Coronavirus (2021) thread

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inbetween said:
At the moment how many people are dying of COVID in the under 30's? How many have even died in the last 3 months?

This is the perfect time to be highly selective of the vaccines we use as we learn more about them.
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As under 30s will be offered a different vaccine, it doesn’t matter, but as you’r asking don’t know about under 30 but 14 under 44 have died this week.
 
Gov UK data delayed due to the previously mentioned delay in Welsh data.

Which has just appeared btw

Wales:

2 deaths - was 2 last week

69 cases - was 126 last week

1.2% positivity- was 1.2% last week (it was a double day data last week so in effect 63 cases then)
 
BlueAnorak said:
They did that because they didn't think the AZ vaccine was as efficacious for the SA variant- not for any other reason. They seem to have ignored the near 100% protection from death bit.
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I think that was the South Africans and the later decision by the (wider) African Union followed the blood clot “findings”. The South Africans had no alternative close to being available IIRC, so it was strange decision to stop the AZ vaccine roll out given the potential protection from death.
 
inbetween said:
At the moment how many people are dying of COVID in the under 30's? How many have even died in the last 3 months?

This is the perfect time to be highly selective of the vaccines we use as we learn more about them.
Click to expand...
In the UK not many, in Europe, quite a lot, in Brazil lots.
The point you are forgetting is the novel nature of this virus. Once you have immunity to the basic Covid-19 virus you are less likely to die from a new variant.Vaccination makes this much less likely.
The variant that is of huge concern at the moment would merge the worse features of the UK, SA and Brazil variants. Rumours are that a US Washington Heights variant (New York state) and a variant in India achieve this.
So best to be vaccinated before the really bad varruant arrives.
 
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Northern Ireland data

0 deaths - was 3 last week

112 cases - was 57 last week

4.2% positivity - was 2.8% last week

Weekly cases rolling total 774 - was 717 yesterday and 650 last week.

Patients 77 - down 7 on yesterday - was 118 last week

Ventilated 5 - down 1 on yesterday - was 9 last week
 
So total deaths today with England out of hospital to come (often weekend catch up added) is 38

It was 17 last week.

And three nation cases with England to come is 402

It was 442 last week.
 
England hospital deaths wk to wk

279 / 59 NW / 26% (25% fall wk to wk)

164 / 35 NW / 21% (41% fall wk to wk)

101 / 26 NW / 26% (378% fall wk to wk)

98 / 19 NW / 19% (3% fall wk to wk)

40 / 8 NW / 20% (61% fall wk to wk)

12 / 1 NW / 9% (70% fall wk to wk)

33 / 8 NW / 24% (175% RISE wk to wk) TODAY

Looks worse than it is I suspect! Hopefully!
 
Chippy_boy said:
Good grief! "After 1 person has died", they want to pause the whole program??? Utter, utter madness. Do they just not understand the "cost of doing nothing"????
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Maybe they do, when from about 193m jabs
98m were Biontech/Pfizer (mRNA),
85m were Moderna (mRNA),
and about 7m J&J (vector).

They have the perfect supply of alternative vaccines to recommend J&J for an age group with a very low risk of thrombosis.
 
roubaixtuesday said:
I think all RNA treatments are linked to thrombocytopenia too?

So arguably equally likely to be a problem for RNA vaccines?
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I don't think the mRNA vaccines are affected.

This is the Abstact of the paper I found. I searched for thrombocytopenia and adenovirus.

My emboldening. I haven't bothered reading it because there's stuff in the abstract such as Willebrand Factor, and P-selectin that I have never heard of but it sounds quite similar to the problems encountered with the COvid-19 vaccines.

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY| DECEMBER 5, 2006,
Volume 109, Issue 7
April 1 2007
Othman et al.

"Thrombocytopenia has been consistently reported following the administration of adenoviral gene transfer vectors. The mechanism underlying this phenomenon is currently unknown. In this study, we have assessed the influence of von Willebrand Factor (VWF) and P-selectin on the clearance of platelets following adenovirus administration. In mice, thrombocytopenia occurs between 5 and 24 hours after adenovirus delivery. The virus activates platelets and induces platelet-leukocyte aggregate formation. There is an associated increase in platelet and leukocyte-derived microparticles. Adenovirus-induced endothelial cell activation was shown by VCAM-1 expression on virus-treated, cultured endothelial cells and by the release of ultra-large molecular weight multimers of VWF within 1 to 2 hours of virus administration with an accompanying elevation of endothelial microparticles. In contrast, VWF knockout (KO) mice did not show significant thrombocytopenia after adenovirus administration. We have also shown that adenovirus interferes with adhesion of platelets to a fibronectin-coated surface and flow cytometry revealed the presence of the Coxsackie adenovirus receptor on the platelet surface. We conclude that VWF and P-selectin are critically involved in a complex platelet-leukocyte-endothelial interplay, resulting in platelet activation and accelerated platelet clearance following adenovirus administration."
 
Healdplace said:
England hospital deaths wk to wk

279 / 59 NW / 26% (25% fall wk to wk)

164 / 35 NW / 21% (41% fall wk to wk)

101 / 26 NW / 26% (378% fall wk to wk)

98 / 19 NW / 19% (3% fall wk to wk)

40 / 8 NW / 20% (61% fall wk to wk)

12 / 1 NW / 9% (70% fall wk to wk)

33 / 8 NW / 24% (175% RISE wk to wk) TODAY

Looks worse than it is I suspect! Hopefully!
Click to expand...
Guessing last Tuesday’s low figure was down to the Easter break and not as many being reported as a result so not really a great barometer.
 
Marvin said:
I don't think the mRNA vaccines are affected.

This is the Abstact of the paper I found. I searched for thrombocytopenia and adenovirus.

My emboldening. I haven't bothered reading it because there's stuff in the abstract such as Willebrand Factor, and P-selectin that I have never heard of but it sounds quite similar to the problems encountered with the COvid-19 vaccines.

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY| DECEMBER 5, 2006,
Volume 109, Issue 7
April 1 2007
Othman et al.

"Thrombocytopenia has been consistently reported following the administration of adenoviral gene transfer vectors. The mechanism underlying this phenomenon is currently unknown. In this study, we have assessed the influence of von Willebrand Factor (VWF) and P-selectin on the clearance of platelets following adenovirus administration. In mice, thrombocytopenia occurs between 5 and 24 hours after adenovirus delivery. The virus activates platelets and induces platelet-leukocyte aggregate formation. There is an associated increase in platelet and leukocyte-derived microparticles. Adenovirus-induced endothelial cell activation was shown by VCAM-1 expression on virus-treated, cultured endothelial cells and by the release of ultra-large molecular weight multimers of VWF within 1 to 2 hours of virus administration with an accompanying elevation of endothelial microparticles. In contrast, VWF knockout (KO) mice did not show significant thrombocytopenia after adenovirus administration. We have also shown that adenovirus interferes with adhesion of platelets to a fibronectin-coated surface and flow cytometry revealed the presence of the Coxsackie adenovirus receptor on the platelet surface. We conclude that VWF and P-selectin are critically involved in a complex platelet-leukocyte-endothelial interplay, resulting in platelet activation and accelerated platelet clearance following adenovirus administration."
Click to expand...
Interesting. Why exactly is the administration of an adenovirus triggering a clotting cascade...
 
England hospital data is a little concerning for a Tuesday that usually shows good falls.

Patients are down - though only by 51 versus 92 last week and 183 the Tuesday before that.

Moreover the NW went UP quite a bit today - patients by 22 and ventilators by 4.

Just one day and let us hope it stays that way.

But ventilators in the SW also rose to double over past 3 days. Admittedly from just 6 to 12.

On the other hand Midlands and Yorkshire both fell by 31 and 33 respectively and London only went up 1.

So may just be a localised blip.
 
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