If it is as likely then where is it? The variants we are tracking are variant in respect of the spike protein sequence which affects its binding ability to the human respiratory cell. We should expect more single point mutations that gradually make it more effective.
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Coronavirus (2021) thread
- Thread starter Ric
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- Where is the Moderna vaccine and what happened to UMRA approval of J&J and Novovax vaccines? In the pipeline?
- Why is is that UK and Europe are so very reliant on overseas vaccine manufacture e.g. India? I know there are UK and European plants but it seems that India seems to be producing half of AZ's vaccine supply. The Vaccine taskforce seems to have done a good job in agreeing contracts with vaccine groups at an early date but manufacturing capacity seems to be a bottleneck that wasn't addressed? I say that knowing very little about bioreactors but I would have thought that a government could encourage diversified production given 1 years notice?
True_Blue69
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If it is as likely then where is it? The variants we are tracking are variant in respect of the spike protein sequence which affects its binding ability to the human respiratory cell. We should expect more single point mutations that gradually make it more effective.
Where’s the one you seem to crave that will avoid all vaccines? Nowhere to be seen just like the mythical one I described.
Gabriel
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Apropos Moderna’s distribution outside of the US.
- Where is the Moderna vaccine and what happened to UMRA approval of J&J and Novovax vaccines?
https://www.reuters.com/article/us-health-coronavirus-lonza-moderna-idUSKBN2B72BB
MillionMilesAway
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- Where is the Moderna vaccine and what happened to UMRA approval of J&J and Novovax vaccines? In the pipeline?
- Why is is that UK and Europe are so very reliant on overseas vaccine manufacture e.g. India? I know there are UK and European plants but it seems that India seems to be producing half of AZ's vaccine supply. The Vaccine taskforce seems to have done a good job in agreeing contracts with vaccine groups at an early date but manufacturing capacity seems to be a bottleneck that wasn't addressed? I say that knowing very little about bioreactors but I would have thought that a government could encourage diversified production given 1 years notice?
Moderna - first doses due in April, apparently.
UMRA? Do you mean MHRA? J&J have only just filed, at the end of February. That's less than a month, and it's all but inconceivable that something would be authorised that fast.
Novavax hope for approval in the UK in May.
AZ have formed partnerships with other companies to make the vaccine - there is no history with AZ making vaccines, and they do not have their own facilities appropriate for it. The contracts were signed long before anyone had worked out what was needed to make them, so they haven't had a year's notice - AZ was only authorised in the UK at the end of December. You also need staff trained to run them, and regulatory assessment of the plant to be able to use new equipment.
There simply aren't that many large scale manufacturing companies for this type of vaccine in Europe - it's also far more expensive than to make vaccines in India. Reagent production, service supply (electricity/water), vaccine production, bottling - it's not a one-stop process, hence the UK making stuff in Oxford or Stoke and bottling in Wrexham (the last two are definitely partnerships, and are not AZ sites).
MillionMilesAway
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What about the variant that doesn’t make anyone ill, but is more contagious and gives anyone that catches it antibodies against any other variant effectively ending the pandemic naturally? Based on no variants outwitting the vaccine, that is just as likely.
I think that's a scientifically illogical construct.
There is no direct connection between contagiousness, lack of symptoms and antibody production, and imagining such a thing is hope not science. No-one knows what would do all of those things, and it's therefore hypothetical.
It is far more likely that a variant avoids the vaccine as it is known how that can happen, and has happened.
True_Blue69
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I think that's a scientifically illogical construct.
There is no direct connection between contagiousness, lack of symptoms and antibody production, and imagining such a thing is hope not science. No-one knows what would do all of those things, and it's therefore hypothetical.
It is far more likely that a variant avoids the vaccine as it is known how that can happen, and has happened.
So it’s scientifically impossible for the a weaker strain of the virus that is less likely to make you ill to emerge but can still cause the body to create antibodies?
Of course it's not impossible but so far the variants of note have either been neutral or more infectious and more virulent.So it’s scientifically impossible for the a weaker strain of the virus that is less likely to make you ill to emerge but can still cause the body to create antibodies?
MillionMilesAway
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So it’s scientifically impossible for the a weaker strain of the virus that is less likely to make you ill to emerge but can still cause the body to create antibodies?
Obviously, I didn't write 'impossible'.
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