Coronavirus (2021) thread

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Bloody hell this weather isn’t helping things!

But they couldn't have gone to restaurants (tier 2) or shopping (tier 3) and it would have made many people avoid the xmas mixing too.

It would have made a big difference - look where cases are surging now.

[Meant as a reply to the previous - obviously makes no sense inb this reply, sorry!]
 
But they couldn't have gone to restaurants (tier 2) or shopping (tier 3) and it would have made many people avoid the xmas mixing too.

It would have made a big difference - look where cases are surging now.

[Meant as a reply to the previous - obviously makes no sense inb this reply, sorry!]
I thought the point being made was about the household-mixing rule being partly relaxed on Christmas Day? Not about shopping or leisure trips
 
Nothing going to waste but it's a headache all the same.
It's difficult to apportion blame as we don't know the individuals circumstances. It's going to be increasingly difficult to play catch-up with those that miss appointments, I'd imagine.
 
Thats the expectation, potentially more too. In terms of the current situation, the briefing I got was that the expectations is back to tiers fully likely to be in march (but everyone being in the higher tiers). Back to relative normality is around June.
So basically schools going back in March, but little else?
 
Nothing going to waste but it's a headache all the same.
It's difficult to apportion blame as we don't know the individuals circumstances. It's going to be increasingly difficult to play catch-up with those that miss appointments, I'd imagine.
Best one I've heard is that a bloke at work was telling people his 80-odd year old mum was due to have her first jab before Christmas but cancelled it because he was taking her to some garden centre near Poulton-le-Fylde for the day! Firstly, she's an idiot for getting her priorities wrong, and he's an idiot for not attempting to talk her out of cancelling her vaccine appointment. Apparently, her new appointment is now at the end of this month but he's going to look beyond stupid if she catches it in the meantime, and that possibility could be higher than the norm because he's been in and out of way more shops than necessary most weekends and also broke quarantine rules when he went round to see his mum a few months back at a time when he should've been self-isolating after returning from Tenerife FFS!
 
I can see us returning nearer to "normal" somewhat sooner. I believe something like 80% of the people currently in intensive care with COVID fall within the category of those scheduled to be vaccinated by mid Feb. Let's say end of Feb.

And here's the key point: Although a single jab may only be 70% effective against you falling ill, it's nearly 100% effective against in terms of preventing you from falling seriously ill and subsequently dying.

So perhaps by mid to end of March, we can expect the load on ICU's to have fallen dramatically. Perhaps by as much as 80%. And of course that doesn't start in the middle of March, it will start to fall 3 or 4 weeks after we started the vaccinations.

Once we have plenty of NHS capacity again (and the chances of individuals dying has dropped very significantly because all of the very vulnerable have been vaccinated) then I am sure the government will want to relax as many restrictions as possible, just as soon as it can.
 
I can see us returning nearer to "normal" somewhat sooner. I believe something like 80% of the people currently in intensive care with COVID fall within the category of those scheduled to be vaccinated by mid Feb. Let's say end of Feb.

And here's the key point: Although a single jab may only be 70% effective against you falling ill, it's nearly 100% effective against in terms of preventing you from falling seriously ill and subsequently dying.

So perhaps by mid to end of March, we can expect the load on ICU's to have fallen dramatically. Perhaps by as much as 80%. And of course that doesn't start in the middle of March, it will start to fall 3 or 4 weeks after we started the vaccinations.

Once we have plenty of NHS capacity again (and the chances of individuals dying has dropped very significantly because all of the very vulnerable have been vaccinated) then I am sure the government will want to relax as many restrictions as possible, just as soon as it can.

The average age in ICU is about 60. ICU load won't drop by more than ~30% at most I would guess with the 70+ categories being vaccinated.

The death toll may well drop by 80% by mid March - I posted some modelling of that upthread. *If* we make the mistake of relaxing quickly as the death toll drops then there is the real possibility, likelihood even, of a surge of virus transmission through the young and middle aged. That would result in a mass disabling of the working population, and probably overwhelm ICUs all over again. Remember the virus can double every 3-4 days without any restrictions.

It's vital that we drive cases down and keep them down as we complete the vaccination programme for all age groups. We did this last year (July cases were <1000 daily) and we can do it again this year when it will be easier (less people susceptible due to vaccination and we know more about transmission).

"Vaccinate the vulnerable and let it rip through the rest" is not a sensible strategy.
 
PH England found 44 health workers (out of 5,500 in a study who caught the virus in the first wave) have been reinfected with Covid. People who have had had Covid may (after recovering from the virus) still be able to carry Covid and pass it on, even though they themselves have protection for at least 5 months.

 
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Summer this year?
No chance there will be any normality by then.

I think that's a bit too negative. I'm more of a pessimist than most and have said on here a few days ago that there's no way any of the big summer things such as festivals or sporting events will go ahead with no restrictions at all but I think to say there won't be ANY sense of normality by July / August is too far.
 
The average age in ICU is about 60. ICU load won't drop by more than ~30% at most I would guess with the 70+ categories being vaccinated.

The death toll may well drop by 80% by mid March - I posted some modelling of that upthread. *If* we make the mistake of relaxing quickly as the death toll drops then there is the real possibility, likelihood even, of a surge of virus transmission through the young and middle aged. That would result in a mass disabling of the working population, and probably overwhelm ICUs all over again. Remember the virus can double every 3-4 days without any restrictions.

It's vital that we drive cases down and keep them down as we complete the vaccination programme for all age groups. We did this last year (July cases were <1000 daily) and we can do it again this year when it will be easier (less people susceptible due to vaccination and we know more about transmission).

"Vaccinate the vulnerable and let it rip through the rest" is not a sensible strategy.

it has allready ripped through the rest. 40 percent of Manchester have had it. Throw in the vaccination and the r rate has to be much lower as there will be far fewer people to get it.
 
Although a single jab may only be 70% effective against you falling ill, it's nearly 100% effective against in terms of preventing you from falling seriously ill and subsequently dying.

This is probably true, but we don't actually know yet. The trials weren't big enough to give quantitative results on severe disease or death.

From the Pfizer and Oxford/AZ phase 3 trials the results were (two doses)

Pfizer active: one severe disease
Pfizer placebo: nine severe disease

AZ active: zero severe disease
AZ placebo: ten severe disease

What does this tell us? severe disease is much less likely, but not impossible on active vaccine full dosing regime. But the numbers are small, so it would be unwise to try and quantify. Confidence limits on % protection against severe disease are not included in the trial results, probably for that reason. I'd guess a confidence interval could be as wide as 70-100% from such a result - and it of course depends on the population. In the real world our initial population vaccinated is massively skewed towards older people, and they may have a different level of protection to the average person on the trial.

There is no clear data reported on the single dose (because everyone on the trial got two), but the data on the interval between the doses shows similar results, albeit with even lower numbers. Other data on immune response suggests that we should expect similar short term efficacy on the single dose, but there is no hard data on this. That's presumably why Pfizer have declined to support the delayed second dose strategy.

There is no data reported on deaths. We should expect a reduction in mortality along with the reduction on severe disease, but this isn't absolutely certain that it's proportional - it could be (much) better or worse. In cancer, for instance, drugs often delay progression of disease but ultimately don't make any difference to ultimate time to death. It *might* be that if you are particularly susceptible to COVID you die regardless of vaccination.

None of this is intended to suggest the vaccines are ineffective, just that we should be a little cautious about *how* effective until we learn more. We should start to know over the next couple of months what the real world protection is.

Pfizer: https://www.nejm.org/doi/full/10.1056/NEJMoa2034577 (table S5)
Oxford AZ: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32661-1/fulltext (table 5)
 
it has allready ripped through the rest. 40 percent of Manchester have had it. Throw in the vaccination and the r rate has to be much lower as there will be far fewer people to get it.

Allowing the remaining 60% to catch it in a short number of weeks would be unwise in the extreme. For the reasons posted.

Yes, the R rate will reduce, but given the rate of increase seen recently, we can be sure it will be >>1 with just 70+ people vaccinated.
 
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