Coronavirus (2021) thread

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www.bbc.co.uk

EU drug regulator: Unusual blood clot is 'very rare AstraZeneca side effect'

The EU's medicines regulator finds the benefits of the Covid-19 vaccine outweigh the risks.
www.bbc.co.uk www.bbc.co.uk

the european regulators still saying the benefits of the AZ vaccine outweigh the risks.

clotting should be listed as “a very rare side effect “

I have had my first AZ and booked in for my second on 17/04 which I will do.

However makes sense to me if there is an effective vaccine without this risk available now for youngsters then it’s a no brainier to give it them.

if you don’t hear from me after the 17.......
 
Regional Scoreboard:

SOUTH

East up 7 to 198

London up 123 to 317

South East up 4 to 222

South West up 28 to 122



MIDLANDS

East up 24 to 225

West up 44 to 256



NORTH

North East up 65 to 139

Yorkshire up 25 to 408


And North West up 69 to 388


Everywhere up modest numbers.

NW close to catching Yorkshire but London up by the most today and now not far behind both.

But all numbers at lowish levels. NW was on 463 a wk ago and Yorkshire 669 and London 402

So all three down wk to wk
 
Whilst I’m certainly sceptical of the benefits of lockdowns and masks I’m certainly not a covid denier or an anti-vaxxer, I do think that understanding relative risk is something that should have been continually explained throughout this pandemic. That messaging should have also been updated whenever new information came to light. All that being said, and given the importance that have been given to vaccines (and rightly so) I do wonder why some of the following isn’t front and centre when discussing blood clots and vaccines.

Every 37 seconds someone in the western world dies from a venous thromboembolism (VTE)
1 in 4 people die from causes related to blood clots
  • In the UK and worldwide, VTE is a leading cause of death and disability
  • Up to 20% of cancer patients develop blood clots
  • Globally up to 60% of blood clots occur within 90 days of hospital discharge
  • More people die from blood clots each year than the total number of people who lose their lives annually due to AIDS, breast cancer, and motor vehicle crashes combined.
  • I would imagine many people refusing the vaccine would accept a free trip to LA. The clotting risk from flying much, much greater than the risk from the vaccine.
  • The MOST likely place you’ll get a clot is in hospital. Don’t take the vaccine because of tiny blood clot risk, catch Covid, go to hospital where your blood clot risk is, in comparison, massive.
 
Healdplace said:
Me included but I d o think this will seriously damage what could have been a global life saver. It has been handled pretty badly too as a PR exercise.
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I think globally it is more likely to just redirect the use - it may pivot away from the first world and instead go to the countries who need the cheap vaccine. It'll be cheap, and they'll probably take the risk in order to get things moving - it'll be the only option.

Here we have alternatives due. If we didn't have alternatives, I suspect a view of the risk would be different for many.
 
west didsblue said:
Exactly right. As can be seen below under 30s have around a 1 in 10,000 chance of dying of Covid if they catch it, and it progressively goes up to 1 in 100 at around 65. If the vaccine has a 1 in a million chance of causing a lethal blood clot, it makes sense for those with a 1 in 10,000 chance of being killed by Covid to hang on a few weeks for the other vaccine whereas if your chance of being killed by Covid is 1 in a 1000 or more you'd risk the 1 in a million vaccine as soon as possible.

10654_2020_698_Fig3_HTML.png
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Is there any inkling (so guess work) which makes AZ potentially cause these blood clots over others such as Pfizer?
I've heard it's down to the supporting lipids but surely with no direct link yet this is nothing more than a possibility?
 
somapop said:
Is there any inkling (so guess work) which makes AZ potentially cause these blood clots over others such as Pfizer?
I've heard it's down to the supporting lipids but surely with no direct link yet this is nothing more than a possibility?
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I have no idea mate. I just know the mechanism by which it works is entirely different to the Pfizer one. From what I've read the overall incidence of blood clots is no worse than with any other Covid vaccine; it's just that it's one type of clot that happens.
 
ive not been following the covid threads for sometime but can someone please brief me up with a couple of questions-

why are under 30s being given an alternative vaccines, are they more at risk than older people from developing clots?

concerning the small threat of blood clots related to AZ vaccine, any idea if these clots were within hours or days after vaccination or are they a small long term risk that could pop up years down the line
thanks in advance if anyone can shed some light,ive googled but nothing
 
Greater Manchester highlights:

192 cases - up 12. - fourth straight sub 200 total.

This is great news as a rise of just 12 from a NW rise of 69 cuts the GM % of the NW total by 6.6% to sub 50% at 49.8% - first time in three weeks below half.

Wk to wk : 341 v 287 v 192


Some very interesting numbers today. With just 32 top to bottom.

Manchester top scores on just 39 - down 15 on wk

Oldham at 33 not far behind and up 12 on the wk (todays most NW deaths were in Pennine Acute too so bad day here)

Wigan clocks up 23 but that is down 14 on week

Bolton one behind on 22 but down 4 on the wk

Rochdale also on 22 but down even more at 6 week to week.

Then Stockport on 19 but doing less well as that is up by 3 wk to wk. Not much damage but up nonetheless.

The other 4 all clocked up VERY low numbers.

Trafford in double figures on 10 - down 13 in the week.

The other 3 ALL had single figure numbers!

Tameside had 9 - down 15 on the week Salford had its second single number - 8 - in the past four days - a huge fall from 43 last week.

And top scoring again was Bury on just 7 -down 8 on the week.

Pretty good day all round with the exception of Oldham particularly and Stockport to a small degree.
 
roubaixtuesday said:
Recommended to get the 2nd unless they had this reaction to the first was what I read. Not absolutely sure.
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Yes that is what was said in the press conference.

I imagine they presume the most susceptible would react to the first dose on being exposed to the vaccine as more likely than the second when the body has already seen it and handled it.

Plus there will be limited numbers who have had 2 doses to judge from, Might change again when more second doses have been given, of course. as we are dealing with very rare events and tiny numbers.

50 or so out of a many millions.

I guess if you worked out how many fell down the stairs in the weeks after vaccination you would come up with a number! But nobody would suggest the vaccine was the reason.
 
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As I see it:
The main (and largely overlooked) point is that regulators issued Emergency Use orders for all the vaccines; none of them have gone through the years-long testing procedures which would normally be needed.

Issues got flagged; the regulators would likely suspend the use order until data on the issue had been reviewed. They have now issued revised regulatory advice with advice by age, just as many drugs say "don't mix with this other drug". As a professional on the BBC has just said, it's "safe but not risk-free" - the regulatory advice will continue to be revised.

This was always going to be likely - it's a learning process, and all the regulatory people will have been looking out for these things.
 
MillionMilesAway said:
As I see it:
The main (and largely overlooked) point is that regulators issued Emergency Use orders for all the vaccines; none of them have gone through the years-long testing procedures which would normally be needed.

Issues got flagged; the regulators would likely suspend the use order until data on the issue had been reviewed. They have now issued revised regulatory advice with advice by age, just as many drugs say "don't mix with this other drug". As a professional on the BBC has just said, it's "safe but not risk-free" - the regulatory advice will continue to be revised.

This was always going to be likely - it's a learning process, and all the regulatory people will have been looking out for these things.
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Yep it's a normal process but with unprecedented media scrutiny.
 
I worry that these vaccines have been too rushed.
This development is concerning.
 
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