COVID-19 — Coronavirus

[Brendan110_0]

Guys why aren't you all on this?

I posted it last night.

Chinese researchers (but based in a Utrecht university have published this in Nature - A human monoclonal antibody blocking SARS-CoV-2 infection, Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands)

They've found an antibody which neutralises the virus. That to me is one step from manufacturing it and you have a vaccine. I am cautious. No one is reporting this.

https://rdcu.be/b3WPD

Edit: FTSE futures are up 100 points. This looks real. Yet to find out why they've spiked but could be linked

Using antibodies - better than nothing but far from ideal, read here (Immunoglobulins);
https://assets.publishing.service.g..._chapter_1_Immunity_and_how_vaccines_work.pdf

 

[Marvin]

Using antibodies - better than nothing but far from ideal, read here (Immunoglobulins);
https://assets.publishing.service.g..._chapter_1_Immunity_and_how_vaccines_work.pdf

Thanks. This one binds to and neutralises the spike protein which would prevent the virus from entering the cell.

I bought into FTSE100 at the market open but it had already spiked 90 points.

 

[Marvin]

Antibodies may work in treatment but they are not a vaccine and there is an awful long way between neutralising a virus in cell cultures and having a treatment that works and is non toxic,
None of which is to say that it is not good news.

The Israelis claim to have done this. Still not on the BBC, but this looks like two research teams working on very similar research and scrambling to be first.

 

[Marvin]

Reuters put the futures rise down to Asian market moves overnight and not linking it to the Covid development but it could be in part, and could lead to further gains in the day.

 

[Cityfan]

The Israelis claim to have done this. Still not on the BBC, but this looks like two research teams working on very similar research and scrambling to be first.

Claim to have done what?

 

[grunge]

Entirely depends on how they want to track it.

For example this is basic anonymised GPS data that is already gained by some companies. If you attach a phone number or ID to each data point and you can track it all off line without anyone having a clue.



Create covid hot spots on that map, ping out an SMS to everyone that passed through said hot spot over a time period and go from there maybe.

will have to take a look at there app when it comes out to get a better idea but there’s plenty of possibilities without much need for something high tech.

I could knock up an app to take your GPS location, unique device ID and phone number and feed it back to a database in an afternoon.

self quote.

this won’t work when indoors. Explains why they want to use Bluetooth to create a contact network. Uptake won’t be high enough I fear tho based on my experience of how many people enable Bluetooth.

 

[Fred_Quimby]

This new app is only any good if someone has been tested positive. If I catch it today how many days before I get the symptoms? If I send for a test and then send it off how many days before the results are known? As I see it we have to be far more efficient in testing for this app to be of any use.

My sister-in-law was tested a week last Friday and still hasn't got a reply. She is 80, in a nursing home with a condition.

 

[BlueAnorak]

The Israelis claim to have done this. Still not on the BBC, but this looks like two research teams working on very similar research and scrambling to be first.

I guess it's a tidge safer than using blood plasma from survivors but that's about it as it does the same job.
Like plasma, it will reduce the number of seriously ill patients needing ventilation by giving the patients own immune response time to kick in.
But It wont do much if anything to stop the Cytokine Storm that kills most patients. Still there will be a good few less patients becoming seriously ill.
It staggers me how long it his taken the NHS to start the plasma trial to be honest. I know they have to wait two weeks (preferably three) before taking blood from those who have recovered but to have only started the trail in my daughters hospital two weeks ago and the rest at the country at back end of last week is the dead hand of beauracracy at work.

 

[Nightmare Walking]

Antibodies may work in treatment but they are not a vaccine and there is an awful long way between neutralising a virus in cell cultures and having a treatment that works and is non toxic,
None of which is to say that it is not good news.

Using antibodies - better than nothing but far from ideal, read here (Immunoglobulins);
https://assets.publishing.service.g..._chapter_1_Immunity_and_how_vaccines_work.pdf

Moboclonal antibodies do work. I was on Infliximab for a while. Thing is, I had to have it pumped into my veins every month, it took a few months for it to work and then my body started having adverse reactions to it after about about 2 years.

Now this stuff the Israelis are working on may be totally different, I have no idea of the science. I just know from my own experience of biological treatments, it was not as simple as an injection and it starts curing you immediately. The side effects were also pretty horrendous for afew days after having it administered.

Long term, a vaccine would be better imo. If biologicals can be used to help keeping people alive then great, as a long term solution, I am a bit dubious.

 

[Cityfan]

I guess it's a tidge safer than using blood plasma from survivors but that's about it as it does the same job.
Like plasma, it will reduce the number of seriously ill patients needing ventilation by giving the patients own immune response time to kick in.
But It wont do much if anything to stop the Cytokine Storm that kills most patients.

I don't think we know enough about the virus yet to know whether it is the cytokine storm that kills most patients or whether reducing the viral replication with treatment will stop the cyto kine storm or whether giving monoclonal antibodies in conjunction with other drugs would stop the cytokine storm.