COVID-19 — Coronavirus

[ColinBellsjockstrap]

Aer Lingus flight from Belfast into Heathrow last Monday

 

[grunge]

1 take on our app.

https://www.theregister.co.uk/2020/04/28/uk_coronavirus_google_apple_api/

headline

UK finds itself almost alone with centralized virus contact-tracing app that probably won't work well, asks for your location, may be illegal

 

[BlueAnorak]

I don't think we know enough about the virus yet to know whether it is the cytokine storm that kills most patients or whether reducing the viral replication with treatment will stop the cyto kine storm or whether giving monoclonal antibodies in conjunction with other drugs would stop the cytokine storm.

According to my daughter, Its definately the Cytokine Storm killing most patients. The frailty of many older patients who can't be put on a ventilator is the other much lower morbidity.

 

[MillionMilesAway]

Moboclonal antibodies do work. I was on Infliximab for a while. Thing is, I had to have it pumped into my veins every month, it took a few months for it to work and then my body started having adverse reactions to it after about about 2 years.

Now this stuff the Israelis are working on may be totally different, I have no idea of the science. I just know from my own experience of biological treatments, it was not as simple as an injection and it starts curing you immediately. The side effects were also pretty horrendous for afew days after having it administered.

Long term, a vaccine would be better imo. If biologicals can be used to help keeping people alive then great, as a long term solution, I am a bit dubious.

Vaccines are definitely preferable. They reduce the number of people who become very ill, and thus the strains brought on by treating them.

Antibodies - pretty much what you say. Each antibody will bind to a small number of virus particles. However virus particles get themselves replicated by the body, meaning you need more antibodies. Capturing all virus particles with antibodies is basically impossible. It does however reduce the amount of virus active in the body, and thus makes patients less ill, and more likely to recover. There can be side effects as you mention, as you're injecting with foreign substances.

The two studies on these may generate different, but similar, antibodies, which is a good thing really. One may be better than the other in the long run, and any first generation antibody will likely be developed further over the years.

 

[BlueAnorak]

1 take on our app.

https://www.theregister.co.uk/2020/04/28/uk_coronavirus_google_apple_api/

headline

We're not the only one though.
Taiwan, Singapore, South Korea, France and Australia are five others not taking the Apple/Google route. There are more besides.

 

[i8rags]

No but it is the foundation for a treatment and that is the conclusion of the study.

Ithink this is what has triggered the Israelis to make their claims

What claims mate

 

[Cityfan]

According to my daughter, Its definately the Cytokine Storm killing most patients. The frailty of many older patients who can't be put on a ventilator is the other much lower morbidity.

I don't think we know that well enough and we certainly don't know what the effect of giving mabs directed at the virus would have on any cytokine storm.

 

[SilverFox2]

According to my daughter, Its definately the Cytokine Storm killing most patients. The frailty of many older patients who can't be put on a ventilator is the other much lower morbidity.

Yesterday it was announced that several hospitals in southern Spain are trialing for a month an arthritic drug that reduces the immune system response that apparently is a big factor in many CV deaths.

 

[BlueAnorak]

Yesterday it was announced that several hospitals in southern Spain are trialing for a month an arthritic drug that reduces the immune system response that apparently is a big factor in many CV deaths.

As so much money is being ploughed into fighting this virus, tne one good thing that could come out of this virus is treatments to stop the immune system going into overdrive.

 

[Saddleworth2]

We're not the only one though.
Taiwan, Singapore, South Korea, France and Australia are five others not taking the Apple/Google route. There are more besides.

Scotland has its own app based on the strategy document issued yesterday. It will only use the UK app (as well as its own) once the UK app proves to be secure.