COVID-19 — Coronavirus

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This is a shit situation but it is a pandemic and not everyone's business is going to survive,i had my own business that I had to give up after my accident so I feel their pain

Packed pubs and trains make me nervous but I I understand that we have to get into our new normal

well it’s good you can be blasé about businesses not surviving - but if you worked in Government you would have a different take on this all. The economic damage has more consequences than just businesses aswell, if people can’t get income then you have to take on stress, anxiety, poor eating etc all contributing to worse health
 
well it’s good you can be blasé about businesses not surviving - but if you worked in Government you would have a different take on this all. The economic damage has more consequences than just businesses aswell, if people can’t get income then you have to take on stress, anxiety, poor eating etc all contributing to worse health
Where was I blase ? The chancellor said at the start he can't save every business,a pandemic will wreck businesses,i was stating a fact and not being unsympathetic,i know how devastating losing a business and income is,i had nothing so I understand

There is a 30 billion beauty industry that is not allowed to work but you can sit for several hours to have a tattoo or pack into the tube or pub,it makes no sense how this is being done,those who have diversified or can reopen will recover
 
Heavy does use of Heperin (anti calagulant), Polatasium and Vitamin D infusions and blood plasma transfusions (in the last week of May).
Remdesivir too on patients who were declining towards requiriing ventilation. Since then it has improved further with the anti-inflamatody steroid they had kicking aound in the drugs cupboard which turns out to be a wonder drug (another 10% inprovement).
Monoclonal antibodies is the next one which will be much better than plasma.

Amazing, thanks. Any timeline for monoclonal yet? Also, I thought the US had bought all the remdesivir?
 
Ok, but my Office area of London (Holborn) is a ghost town and has been for a good few months because we’re all working from home -
Normally if everyone’s in the office , come lunch time and after hours all the shops are extremely busy and all the pubs are packed.
Not to mention the cost of travel to London.

it’s great that we can all work from home but it is decimating the economy of these areas.

Interesting - I work in the Bloomsbury square area & haven’t been back in the office since March.

Was wondering how busy the area is now, as in the summer it’s normally packed full of tourists due to the proximity of Oxford Street.
 
Poor old Bill Gates gets some royal stick on the far flung reaches of twitter.
There are some utter loons out there. Anyone heard of Beachmilk account (me neither till ten mins ago). Eye opening some of the theories they push out. Kurazee.
This is one of the less bizarre claims.
Who needs tiger king...


 
Poor old Bill Gates gets some royal stick on the far flung reaches of twitter.
There are some utter loons out there. Anyone heard of Beachmilk account (me neither till ten mins ago). Eye opening some of the theories they push out. Kurazee.
This is one of the less bizarre claims.
Who needs tiger king...




Blimey. The cuts aren't even subtle. I presume they're taking things he says totally out of context.
 
Around 12 to 16% would have been my intuitive guess. Say with lockdown 20% of the population are likely to be exposed to the virus. So by the time the curve has passed its peak and is well on the way down I'd have expected about 60 to 80% of those to have encountered the virus some way or another; so 12-16% of the whole population should be showing antibodies.

That's where my, now rusty, microscopist's mindset clicks in. As I understand it corona viruses (generally) have specific binding sites on the cell surface. There are also suggestions (though not peer reviewed) that folk with "O" blood type are less susceptible to contracting the virus whilst "A" & "AB" blood types were more susceptible to contracting the virus. As I understand it blood types are related to differences on the surface of red blood cells. I also understand that part of the mutation that allows viruses to jump across species relates to changes in the protein spikes that allow the virus particles to attach to the surface of cells. So to me there seems to be a possibility that some folk are naturally more resistant to the virus because their cell surfaces do not have or have fewer available, binding sites. Of course further mutations during the course of a pandemic could reduce this specificity.

https://www.nature.com/articles/s41594-019-0233-y
https://www.livescience.com/why-covid-19-coronavirus-deadly-for-some-people.html

This is why I'm puzzled: if I were building a mathematical model to predict how the virus would spread across a population, or at what level "herd immunity" might become significant I'd want to factor in what proportion of the population had more/less natural resistance. Nothing that I have heard suggests that this is being taken into account, although I realise that it is difficult to assess. Perhaps some folk on here have a wider insight into this issue than I.
You are conflating two separate questions.
Susceptibility to infection and susceptibility to severe disease.
No one knows or can model how previous coronavirus infections can affect either.
Blood group may well affect severity of disease but is not thought to affect susceptibility to actual infection it isn't impossible but then not are a lot of random variables.
 
Poor old Bill Gates gets some royal stick on the far flung reaches of twitter.
There are some utter loons out there. Anyone heard of Beachmilk account (me neither till ten mins ago). Eye opening some of the theories they push out. Kurazee.
This is one of the less bizarre claims.
Who needs tiger king...




Bill Gates has saved more lives than any other human in history and the thanks he gets is right wing wackjobs using the home computers he pioneered to shit on him.
 
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