COVID-19 — Coronavirus

[mosssideblue]

They are one and the same. You want to move it without affecting the temperature.

When we work these storage temperatures out what we do is set non-arbitrary values we aren't willing to go beyond.
For example, we know that the degradation pathway of A is to become B. Therefore we set a maximum amount of B before we know it impacts the effective level of A.
Then we run that test. We place it under various conditions to see how quickly it becomes B. It's a natural progression to go from 24 to 72 hours to 1 week. When the clinical trials are designed they have to account for the time it'll likely be out of ultra cold storage - this is a risk assessment borne of a worst-case-scenario.

In this case I'd bet my life they know 5 days is adequate for use of the vaccine (2-8c) and that -70c doesn't give rise to degradation. Why go further? There's no reason to. It may not have even passed clinical trials p1. You don't invest time and money into whatiffery.

Are you saying that the vaccine doesn't deteriorate at - 80, but as son as you bring it up to normal fridge temperatures, the clock is ticking before it goes off, and that is about 5 days?

 

[Marvin]

What's the significance of the transportation temperature as oppose to the storage temperature?

You know of a permanent supply of dry ice?

 

[03 March 2002]

I'll say thanks for your detailed reply, although haven't a clue what that all means.

No doubt you can tell this wouldn't be my Mastermind subject.

No problem.

If I can try to add some more explanation to my post, it would be that storage is a method of preventing loss of a product. Loss mostly occurs a result of degradation in biological systems and therefore storage is another way of saying control of degradation.

Unless we find a way of hitting absolute zero some level of chemistry will always occur and therefore freezing something merely slows down the progression of degradation.

I'm sure your mastermind subject would put me on the other side of the table.

 

[03 March 2002]

Are you saying that the vaccine doesn't deteriorate at - 80, but as son as you bring it up to normal fridge temperatures, the clock is ticking before it goes off, and that is about 5 days?

Doesn't is not correct but for all intents and purposes that's true yes. You description here is probably quite spot on for the average person to understand what's happening here.

Also, scientists will rarely ever say this happens at this time. What's more correct is that it has only been tested up to the 5th day and such we can only say it's stable for 5 days.

 

[Len Rum]

Cases not far off 25% down on 3 weeks ago. Good news.

Shame about the deaths.

 

[idahoblues]

Weird that now Trump has been voted out, new cases are surging (at least locally) How can that be? Everyone knows it was a democratic plot to take down Trump

 

[domalino]

Because if arguably the largest pharma company in the world are doing their job correctly (they are) they will be running stability studies in parallel to determine what temperature to store and transport at. The starting point is always cold as possible and work from there for biologics.

Order of importance:
RT > Fridge (2-8c) > Freezer (-20c) > Ultra low (-70-80c)

I'm quite interested in this.

Are you saying they've likely not had time to work out what temperature it has to be stored at yet and -70C is just the default position they take until they've worked out how long it takes to degrade at -20 or 2-8?

I would have thought that would be something they'd do straight away because of its ramifications for the logistics of widespread rollout.

 

[domalino]

No problem.

If I can try to add some more explanation to my post, it would be that storage is a method of preventing loss of a product. Loss mostly occurs a result of degradation in biological systems and therefore storage is another way of saying control of degradation.

Unless we find a way of hitting absolute zero some level of chemistry will always occur and therefore freezing something merely slows down the progression of degradation.

I'm sure your mastermind subject would put me on the other side of the table.

By this are you saying that they would need it to be at -70C for long term storage but that it's possible it is delivered out to inoculation centres from a regional hub and kept at -20C for a few hours while the vaccine doses are being administered?

 

[Healdplace]

Only 24 of the 361 England hospital deaths today were under 60 and none were under 40.

More than half were over 80.

 

[mosssideblue]

You know of a permanent supply of dry ice?

Not sure what you are asking