We stayed at Universal (Sheraton hotel) and never went to the theme park. It was perfect because it's next to 101 and Burbank airport is 20 minutes up the road. You can fly in from Vegas, hire a car (or Uber) and be in your hotel almost within the hour whereas with LAX you can at least treble that.
Another thing worth mentioning and one downside to having a car is the parking is CRAZY expensive and it will likely be $20-$40 per night at most decentish hotels.
The one place I'd avoid on most peoples list is the Hollywood Walk, it's one of those supposed glamorous places that actually is a bit of a sh*thole. If you like watching people muck about whilst trying to sell you shite then it's the place to go.
Watch for earthquakes as well (not that you can lol), we were there for the 6.4 and 7.1 last year, very weird!