The 'fully fit' part of my comment was the bit to focus on.Aguero always takes half a dozen games to find his form,had he not had a relapse and fate been kinder,then he would probably have been in peak form for Sunday.As i said,the signs aren't good for Mendy as he just cannot sustain a consistent run in our team.....should he manage that,then i still believe he will be a great player for us.Dinho might not be the force he was,but he can still be a fantastic option and influence.
So IMO the absence of all three,when fully match fit,does matter,as they all improve our squad and subsequently our chances of success.