It will be horses for courses. When we go away to Stoke, Bolton, Birmingham (and similar places like that), i'd play Richards and Lescott as full backs, with Toure and Onuoha in the middle. This gives us maximum height and power to deal with the physical and aerial onslaught from both open play and from set-pieces.
In home games against really poor opposition that park the bus, i'd go with Zab and Sylvinho as full backs as they are in my opinion, better than Richards and Bridge at going forward. Zab and Sylvinho's width and constant bombing runs will make all the difference when overcoming these negative teams. Then, i'd have Lescott and Toure in the middle.
In all other games (the non-physical away games and the home games where teams actually try to attack us), i'd go for Bridge at left back, as he is more all-round than Sylvinho and Lescott as a full-back. As for right-back, i'd be ever so slightly inclined to go for Richards because we are a fairly small team and his height (or more specifically, his leap) will be important. But it really is a close call between him and Zab. Again, i'd go for Lescott and Toure in the middle for these games.
Of course, if someone is massively out of form, the above would have to be reconsidered. But right now, this is how i'd go. It really does depend on the opposition and the expected style of the game that's to be played.