COVID-19 — Coronavirus

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Churchlawtonblue said:
I agree and you clearly clearly know more than I in this field. However, if the regulator agrees its safe at either dose as that report says then its doesn't matter, they just need to approve and get it rolled out. Delaying it needlessly to see which is the more effective does will surely result in more deaths in the interim, just go with one and half jabs? That's the point i was trying to make. Cheers
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I agree with you - but noting that the regulator could decide more safety data was needed on the lower dose before approving, rather than more efficacy.

If it's got a different efficacy profile, it's conceivable it could have a different safety profile too - either better or worse.

It seems unlikely to me, but I don't have the knowledge to be remotely definitive.

I think I posted above, my guess is that they'll approve the lower dose but with a condition of completing a larger trial on that dose. The view seems to be that the FDA will not approve without that data first. It's not particularly unusual for different regulators to make a different call on issues like that.
 
GM total today is up 12 to 493 so pro rata the % of the NW total stays much the same given the tiny changes.

The big news is that all ten boroughs were below 100. Including Manchester.

Many places were at low levels. One borough that was actually sub 20 cases today. Very rare since late Summer.

Not the best day for Stockport. No disaster but it rises a bit up the list and closest to Manchester than for a long time. Its hold on the Pop Score record is crumbling.

Indeed such is now the closing of the differences between boroughs that the gap between all 10 boroughs today top to bottom is just 77. Lowest in ages,
 
The Lancet Study shows that not only was the LD regime younger in age profile it was skewed to have 65% women who as we all know have a better Covid outcome. The other populations were also skewed towards women but not so much.

It's also worth making the obvious point that the report is by the Oxford vaccine group i.e. in-house
 
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PannickAtTheDisco said:
what are the axis measuring?

See Oxford had 2 notable problematic events associated with it, would like to see more explanation on those going forward. Let's see how Pfizer does in the real world.
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The X axis is time and the y axis is number of cases so essentially 10 days after the first dose there were very few cases in the vaccine group(8)but in the placebo group they were accumulating at a steady rate.

I have edited the post it was 8 occurrences not 3 as I had originally put in I was getting my trials mixes up
 
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Marvin said:
The Lancet Study shows that not only was the LD regime younger in age profile it was skewed to have 65% women who as we all know have a better Covid outcome. The other populations were also skewed towards women but not so much.
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They have a better outcome but the incidence of symptomatic covid is not known to be different as far as I'm aware and the placebo comparator for the low dose had 68% women.
 
The Telegraph report on the Lancet article is more negative than I expected and seems to imply that the Oxford vaccine will not be of much use in the next few months as the only dose regime likely to be approved has no established evidence of preventing onward transmission - which they think is essential in a wider use of a vaccine to prevent spread.

Given how much the UK seems reliant on this one vaccine over the next few months as the US one seems to be in shorter supply than we have been suggesting. Not 10 million doses but more than 5 is what they were seemingly saying this morning.

Then is that negativity over reaching by the paper or a genuine concern? As the mood here seems better. And some of you will understand the science much better than I do.
 
I imagine a problem will be asking people to take a vaccine that has a 60% or so efficacy and has had doubts cast on it versus the one being used now that has a claimed much higher success.

How many are going to say they will wait until they can have the 'better' one? I can see that being an issue.
 
Healdplace said:
The Telegraph report on the Lancet article is more negative than I expected and seems to imply that the Oxford vaccine will not be of much use in the next few months as the only dose regime likely to be approved has no established evidence of preventing onward transmission - which they think is essential in a wider use of a vaccine to prevent spread.

Given how much the UK seems reliant on this one vaccine over the next few months as the US one seems to be in shorter supply than we have been suggesting. Not 10 million doses but more than 5 is what they were seemingly saying this morning.

Then is that negativity over reaching by the paper or a genuine concern? As the mood here seems better. And some of you will understand the science much better than I do.
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The Telegraph has gone very click baity as it chases subscribers (I have a modded app to get premium for free). I read that article before seeing your post & I thought it was shite (the article).
 
Invisible Man's Bandage said:
The Telegraph has gone very click baity as it chases subscribers (I have a modded app to get premium for free). I read that article before seeing your post & I thought it was shite (the article).
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Thank you Hope that's it. But negative publicity will not help the drive to get people to take it and 'which one are you giving me?' will be trending no doubt!
 
Healdplace said:
Thank you Hope that's it. But negative publicity will not help the drive to get people to take it and 'which one are you giving me?' will be trending no doubt!
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Much more positive from The Times

www.thetimes.co.uk

Oxford-Astrazeneca Covid vaccine shows sign of giving herd immunity

The makers of the Oxford vaccine are the first to provide evidence that it may stop asymptomatic infection in a crucial sign that it could provide herd immunity.In a further dilemma for regulators, however, the strongest effect seems to come from the half-dose regimen that was discovered by chance.S
www.thetimes.co.uk www.thetimes.co.uk
 
Healdplace said:
I imagine a problem will be asking people to take a vaccine that has a 60% or so efficacy and has had doubts cast on it versus the one being used now that has a claimed much higher success.

How many are going to say they will wait until they can have the 'better' one? I can see that being an issue.
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My daughter got her second dose of the Novavax vaccine today as part of the trial. She was chatting to the Stepping Hill nurse who was administering it and asked how soon SHE would be given the vaccine. The nurse said she would hold out for the Novavax as she knew more about it. But that could take months as the trial only started the end of September.
 
Blue Maverick said:
Because when she comes on tv having ago at someone for breaking the rules it willl come straight back at her.
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She is a news presenter. She is interviewing people for the benefit of the viewers. Not sure why that means she should be judged to different standards to you or I.
 
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