The loss of Aguero and Silva is huge, our key striker, and our most creative player, both missing. It's not just that Aguero is our best striker, it's the TYPE of striker he is, the exact type that Smalling, and particularly, Jones have nightmares about. Give them a Wilfried Bony style of player all day, but a short, stocky, tricky, quick player with excellent movement will tie them up in knots. Remove the creative hub from behind the striker too and it makes their job, defensively, a shit load easier than it should have been. One thing is almost for certain, United will score. We haven't kept a clean sheet in any of our last 7 games, and that's included games against West Ham, Newcastle, Sunderland and Bournemouth. We need 2 as a minimum to win, and possibly 3. We are more than capable of scoring, we've scored in all 12 games this season, in all competitions, and we've scored 11 in the last 2 league games, so up front isn't our issue.
I suspect we'll bring Kompany back in, probably in place of Otamendi, but assuming Kolarov isn't going to be fit I think we'll likely go with the same lineup otherwise.