Why wouldn't UEFA postpone and move the final from Istanbul? They postponed and moved it last year under the same circumstances. Istanbul would be a much better tourist destination in 2022, Istanbul and Turkey would be promoted in a much better light.
Under present conditions, at best, only a handful of fans would be able to travel instead of tens of thousands. The local economy would be boosted significantly with a fan packed city. Doesn't make economic sense apart from anything else. There are several quite viable and more Covid free cities who would gladly accept the opportunity.
If we are talking a City/Chelsea final, and we'll know on that in just six days time, then somewhere like Cardiff is a no brainer.
Otherwise, as posted earlier, New York would be a brilliant stage for Europe's finest to present/promote football (soccer) to that vast, and still relatively untapped, market. A golden, and fortuitous, opportunity not to be grabbed by UEFA. An absolute money spinner, isn't that UEFA's philosophy.