I can't see there being anything like the turnover some are suggesting. Might be nice, but I just don't think it will be possible.
I'm also not convinced that we necessarily need quite so many changes. So far this season we've mauled the rags for 45 minutes at the swamp, outplayed Barcelona at home, battered Chelsea for 60 minutes or so, and taken apart both Spurs and Arsenal for long spells at home. And all that with various combinations of the likes of Sagna, Zabaleta, Otamendi, Kolarov, Clichy, Fernando etc. on the pitch. So I'm not sure I buy the idea that we have so many players who cannot possibly play in a Pep team. The challenge is to get us playing with the requisite energy, effort, desire, bravery, nouse, tactical awareness etc. over the full 90 minutes, week in, week out (or as close to that as possible). And that's got as much to do with our bigger players as it does with the weaker ones.
All that being said, we obviously need a few to be brought in - left-back very obviously, probably a centre half (again!), and possibly a deep-lying midfielder. Ideally, an extra wideman, too, to supplement Sane and Sterling. And I certainly wouldn't be too upset to see most on the initial list go (except Aguero and Fernandinho. And Vinny if there is the faintest hope of him playing on).