COVID-19 — Coronavirus

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marcus said:
Maybe some need the optimism to keep going.
Im sponge for positivity and negativity. So any positive news lifts me.
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The AstraZeneca vaccine should be getting approved in the next week, which will be a game changer as it's so much easier to distribute and they've already got 15 million doses waiting to be put into vials and shipped.
 
kippax4ever said:
I dont no how you come to that conclusion.mate.
When clapping for the NHS,
There were illegal raves going on around the country with thousands in attendance,besides other fkwitts disregarded the rules.
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Imagine we had no source of media, we would be completely f*cked!

all the rules on social distancing, hand washing, contagious areas etc have been given to us via the media.
 
Marvin said:
Confirmation of your comment here:

Summary of mutations by UK genomics
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Thanks, that's a well-written document.

The A222V mutation is a good indicator - a lot of occurrences but probably of very limited effect; A and V amino acids are chemically very similar and also chemically quite dull, so the mutation is probably not important.

As antibodies (natural or derived by vaccine) work on making a square cover to fit on a square peg of the virus, the problems come when the mutation turns the square plug into a non-square cover (due to the 3d shape of the virus and antibody).
 
domalino said:
The AstraZeneca vaccine should be getting approved in the next week, which will be a game changer as it's so much easier to distribute and they've already got 15 million doses waiting to be put into vials and shipped.
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This may already have been answered, but is the AZ vaccine just as likely to work against the new mutation as the BioNTech one or does this this differ due to the different makeup of the two vaccines? Is AZ potentially in more trouble or potentially better placed?
 
domalino said:
The AstraZeneca vaccine should be getting approved in the next week, which will be a game changer as it's so much easier to distribute and they've already got 15 million doses waiting to be put into vials and shipped.
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That's as I see it too. As soon as that passes, every GP and many pharmacies will get boxloads of the stuff, and quite possibly other big centres too for anyone not registered. Many will be happy to open for long hours to get it done.

Setting e.g. army medics and any volunteers trained in injections would allow fairly high throughput in sports halls, etc.

The difficulty is probably recordkeeping.
 
ayrshire_blue said:
This may already have been answered, but is the AZ vaccine just as likely to work against the new mutation as the BioNTech one or does this this differ due to the different makeup of the two vaccines? Is AZ potentially in more trouble or potentially better placed?
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No way to be certain, but likely to be the same basis.

All three work on the spike protein, so if the psike protein doesn't change too much, they will probably work.
 
MillionMilesAway said:
No way to be certain, but likely to be the same basis.

All three work on the spike protein, so if the psike protein doesn't change too much, they will probably work.
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Thank you, that puts me at ease slightly. Had it in my head somehow that the BioNTech one was a completely different profile from AZ and as such the AZ possibly didn't have the same confidence against such mutations as this.
 
Manc in London said:
Politically, that may prove a tad unpopular.
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Only for those who have yet to understand the implicatons of a virus doubling every 6-7 days in an enormous population centre. Of course we must assess the impact of Tier 4, and effectiveness, and availability of vaccines.

My worries are abating a little because no one yet has said that there is an issue with the vaccines and I find it unthinkable that they haven't been looking at this for some while. I also find it reassuring that no reinfections have been reported.

In one sense we are really unfortunate that this has occurred at this moment. On the other perhaps we are fortunate that it did so now and not earlier. On the other hand, perhaps it occurs now precisely because the virus is coming under selective pressure i.e. we will see more variants in future.
 
MillionMilesAway said:
That's as I see it too. As soon as that passes, every GP and many pharmacies will get boxloads of the stuff, and quite possibly other big centres too for anyone not registered. Many will be happy to open for long hours to get it done.

Setting e.g. army medics and any volunteers trained in injections would allow fairly high throughput in sports halls, etc.

The difficulty is probably recordkeeping.
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any volunteers trained in injections,

Well am stating now I want a medical trained person & not..
images (13).jpeg
 
German scientist on BBC saying probably all over Europe but they don't have as much sophisticated equipment to detect variants.
 
shemnel said:
updated those to "today" for you;


View attachment 7013

View attachment 7014
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Appreciate these graphs you post. Makes it nice and simple for me.
Although it does depress me living in the area with the lowest figures in Lancashire, and neighboring the second and third lowest. However I understand we are all in it together.
Have been quite surprised throughout the pandemic how few have died in Fylde considering its renowned for being God's waiting room.
 
ganganvince said:
German scientist on BBC saying probably all over Europe but they don't have as much sophisticated equipment to detect variants.
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this is surely the case and could be what is driving some bigger numbers round and about recently. In the UK we do lots of sequencing i believe, compared to other countries
 
shemnel said:
this is surely the case and could be what is driving some bigger numbers round and about recently. In the UK we do lots of sequencing i believe, compared to other countries
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Could even turn out we imported it.
 
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