The proper facts are that mutations like L452R in the Indian variant are related to the following escape antibody reactions: mAb bamlanivimab, mAb class2, mAb class2/3, mAb COV2-2096, mAb P2B-2F6, mAb regdanvimab, mAb S2D32, mAb S2H70, mAb S2N12, mAb S2N22, mAb S2X30, mAb S2X305, mAb S2X58, mAb S2X608, mAb S2X609, mAb S2X619, mAb SARS2-01, mAb SARS2-32, mAb X593.
That's one mutation.
There are some neutralising antibody reactions that remain unaffected. That is why we now need high antibody titres to get an effective neutralisation hence you need two jabs.
If you check the relevant databases you will find that there are 19 new mutations that have been detected in the new variant just whilst it has been circulating in the UK. Fingers crossed that we don't get any that will KO any of the remaining neutralising antibody reactions.
There are other aspects to immunity than antibodies but it isn't all good news. The vaccines remain effective for the time being against the major circulating strains. And I think we this current spike will be short-lived. My concern is what happens after it sweeps the world. Where will that leave our immunity? I don't know but we should be very wary.