Oh yes you do! If needed, that is exactly what you are going to do. I repeat, if needed, for those who need it -which is Guardiola's call.
You follow objectives, and you set your priorities accordingly. The league title is already won, I do not give a fuck (neither does History...) when City will win it mathematically. But we're talking about a CL QF here. You fuck up there, you won't be able to fix it. The opportunity is lost permanently, you'll have to wait for next season again...
These players have worked their asses off to achieve such an advantage. Some of them may need protection, we'll see. Obviously the result of the 1st leg is expected to play a major role in this, the injury status of the squad, individual form etc. What I mean is that, in any case, this is a luxury City can afford, while Liverpool cannot. Their CL football next season is a question mark at the moment, with Chelsea 4 points behind, and 8 matches to go. So they are obliged to give everything on both competitions -another factor that could have an influence in the matches between us...