Coronavirus (2021) thread

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Back of the cigarette packet time,but J&J initiated the single-dose Phase 1&2 trial on July 22nd 2020 and have their Phase 3 results now, so six months. In the interim, they initiated their double-dose Phase 1&2 trial on November 15th, so presumably they’ll have an inkling of the results of that and its Phase 3 around May 15th, which ought to be about the time they actually start delivering stocks.
If the double-dose proves significantly more effective, then would it not be prudent to wait and see before deciding which protocol to follow?
 
Gabriel said:
Back of the cigarette packet time,but J&J initiated the single-dose Phase 1&2 trial on July 22nd 2020 and have their Phase 3 results now, so six months. In the interim, they initiated their double-dose Phase 1&2 trial on November 15th, so presumably they’ll have an inkling of the results of that and its Phase 3 around May 15th, which ought to be about the time they actually start delivering stocks.
If the double-dose proves significantly more effective, then would it not be prudent to wait and see before deciding which protocol to follow?
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Well, I'd guess it will be at least a month, more likely two before these results are submitted and approved, so the alternative is just to get on with the one dose, and then double up if the second dose looks to significantly improve matters?
 
Healdplace said:
Scotland data: 3 wks v 2 wks v last wk v Today

deaths / cases / % positivity / patients / ventilated


93 d / 2309 c / 8.1% / 1530 p / 102 v

61 d / 2160 c /7.5% / 1860 p / 141 v

71 d / 1480 c /6.9%/ 2053 p / 161 v

70 d / 1155c /5.8% / 1958 p / 144 v Today

This looks a very promising track suggesting a plateau last week and now falling.

Similar to what appears to have occurred in England.
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Early signs but good news for Scotland and hopefully the rest of us.
 
roubaixtuesday said:
Well, I'd guess it will be at least a month, more likely two before these results are submitted and approved, so the alternative is just to get on with the one dose, and then double up if the second dose looks to significantly improve matters?
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I thought it was going to the regulators next week, so a month or so for authorisation of the one-dose option?

I'd think they will have data for following up the current one-dose with a second, as well as any independent new two-dose option.

I think they must expect it to be authorised or they wouldn't submit; they can then start making/running the equipment so they're ready to go.
 
Wales data 3 wks v 2 wks v last wk v Today

deaths / cases/ weekly pop/ % positivity / patients / ventilated


56 d / 2487 c / ???/ 20.6% / 1940 p / 143 v

54 d / 1808 c / Pop 372 / 9.5% / 1881 p / 135 v (13, 402 first dose vaccinations)

67 d / 801 c / Pop 271 / 12% / 1832 p / 134 v (21. 882 first dose vaccinations)

29 d / 546 c / Pop 172 / 4.1%/ 1745 p / 134 v (26, 182 first dose vaccinations) Today


This if anything looks better than Scotland
 
I expect the J & J will be the basis of the annual winter Covid jab on current evidence.

A single shot one is certainly needed for that.
 
Healdplace said:
Wales data 3 wks v 2 wks v last wk v Today

deaths / cases/ weekly pop/ % positivity / patients / ventilated


56 d / 2487 c / ???/ 20.6% / 1940 p / 143 v

54 d / 1808 c / Pop 372 / 9.5% / 1881 p / 135 v (13, 402 first dose vaccinations)

67 d / 801 c / Pop 271 / 12% / 1832 p / 134 v (21. 882 first dose vaccinations)

29 d / 546 c / Pop 172 / 4.1%/ 1745 p / 134 v (26, 182 first dose vaccinations) Today


This if anything looks better than Scotland
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That is so fucking damn good stuff. Huge drop in deaths, cases down, patients down, positivity plummeting and vaccinations up! Cmonnnnn Wales.
 
Good news day continues

744 England hospital deaths - well down on the 993 last Friday.

Biggest week to week fall in ages.

We may be seeing the first signs of the vaccine plus lockdown working

North West though still up at about 13% - slightly up on recent weeks and possibly the legacy from being the last region to get the big numbers pre the lockdown.

But happily we probably got in JUST in time to stop these numbers getting out of control. And that is really only 1 or 2 % up not the huge increases seen in December in the southern areas.

Deaths lag, of course, so we are likely still seeing the result of some of those tragedies that started before it began.
 
Healdplace said:
Good news day continues

744 England hospital deaths - well down on the 993 last Friday.

Biggest week to week fall in ages.

We may be seeing the first signs of the vaccine plus lockdown working
Click to expand...

And we still have at least 38 days until proper lockdown ends with the schools going back. Should be another 8-12 million vaccinated by then and cases and deaths should be miles down.
 
England hospital deaths 3 wks v 2 wks v last wk v Today

717 / 82 NW / 12%

807 / 90 NW / 11%

993 / 94 NW / 10%

744 / 94 NW / 12.5% Today
 
urban genie said:
J&J vaccine 66% effective


Nah fuck that I will stay indoors and wait to get the other ones
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That is on a par with the flu jab every year.

And what matters as is said over and over as it is true is not getting REALLY ill from it as opposed to catching it and it being not much milder than death.

If you just have a winter bug not a death sentence really that is what matters with these vaccines. Especially as it saves the health service from seeing hospitals swamped that kill others by the fall out.

It is going to be a hard struggle getting many people to see this though if these figures are not properly explained.
 
Healdplace said:
That is on a par with the flu jab every year.

And what matters as is said over and over as it is true is not getting REALLY ill from it as opposed to catching it and it being not much milder than death.

If you just have a winter bug not a death sentence really that is what matters with these vaccines. Especially as it saves the health service from seeing hospitals swamped that kill others by the fall out.

It is going to be a hard struggle getting many people to see this though if these figures are not properly explained.
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Spot on.

There are no guarantees that having any vaccine with prevent you from getting Covid but all of them appear to hugely reduce the chances of becoming seriously ill or dying.

The J&J vaccine appears to be highly effective as a single shot vaccine and possibly it might be backed up with a second dose depending on the outcome of the ongoing trial.
 
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