The more I think about this, I think we should go 4-4-2.
First off, I don't think Mourinho will be expecting it, so that's a positive way to start. But secondly and more importantly, I don't think we need to pack the midfield in the same way as if we were facing an attacking side going all out for the win. I am 100% covinced Maureen will be playing to not get beaten on Saturday. It would be madness not to in his position, and combine that with his naturally defensive-minded mentality and it is inevitably the way he will set them up.
They will allow us lots of possession in harmless areas and they will defend deep and be very organised. Doubtless they will mark Silva out of the game, or at least try to, with Matic and Willian. I don't see them trying to boss the midfield at all to be honest. And if we play with only Aguero up front on his own, not getting much service from Silva, and likely none at all from Navas, Fernandino, Fernando and perhaps Milner, I can't see us breaking Chelsea down.
But play 4-4-2 and we have a good chance. Dzeko will keep Terry and Cahill (assuming he plays) very busy and Aguero will run in and around and in between and cause havoc.
Yes it's risky, but so is playing 4-5-1. If we play with only 1 striker, I'd back Chelsea to score on the break as being more likely than us breaking down their defence. I think 4-4-2 is our best option.