Jermaine Jenas is a doubt as he is struggling to recover from food poisoning. The England international returned to training today but is a major doubt for Harry Redknapp's side who will also be without Ledley King (knee), Jonathan Woodgate (groin) and Carlo Cudicini (wrist and pelvis).
Redknapp confirmed that Luka Modric (leg), who has not started a game since August, will be on the bench while Roman Pavlyuchenko and David Bentley are also in contention despite being left out of Saturday's squad.
Shaun Wright-Phillips will definitely miss the game for Manchester City. The England international was forced out of Saturday's draw at Bolton after aggravating an ankle injury and is already a doubt for Saturday's encounter with Sunderland.
Craig Bellamy is suspended for the trip to White Hart Lane but Nigel de Jong has recovered from swine flu, while fears that Emmanuel Adebayor was about to be laid low by the illness have proved unfounded.
Tottenham Hotspur (from): Gomes, Alnwick, Dawson, Assou-Ekotto, Bale, Corluka, Bassong, Huddlestone, Lennon, Kranjcar, Jenas, Palacios, Hutton, Crouch, Defoe, Bentley, Keane, Pavlyuchenko, Giovani, Modric.
Manchester City (from): Given, Taylor, Richards, Zabaleta, Toure, Lescott, Onuoha, Sylvinho, Garrido, De Jong, Kompany, Ireland, Barry, Robinho, Petrov, Adebayor, Tevez, Santa Cruz, Weiss, Benjani.