To the game from town, yes. After the game, walk back into town to catch tram home from Pic/Market St/ Shudehill.
Its straightforward , and I get some fans have longer journeys.
As an away fan , getting away from Anfield/ Goodison/ United/ Spurs /Leeds/West Ham etc etc. has never been easy, its not just an Etihad issue. I was in Liverpool last week with an Evertonian mate, who who took me to the Hill Dickenson on a non match day. Its further out from Lime St than City is from Piccadilly. about a 40+ minute work. The nearest small Merseyrail station, Sandhills, is about a mile from the from the new ground and has similar long queues after the game. Should be fun.